Sökning: "glycosaminoglycans"

Visar resultat 1 - 5 av 72 avhandlingar innehållade ordet glycosaminoglycans.

  1. 1. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Författare :Kristina Mårdberg; Göteborgs universitet.; Gothenburg University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Sammanfattning : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. LÄS MER

  2. 2. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention

    Författare :Kicki Bergefall; Göteborgs universitet.; Gothenburg University.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HSV; glycoproteins; glycosaminoglycans; virus receptor; antiviral drugs;

    Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER

  3. 3. Unraveling the molecular mechanisms of herpes simplex virus attachment and release using cell membrane mimics

    Detta är en avhandling från Gothenburg : Chalmers tekniska högskola

    Författare :Nadia Peerboom; [2018]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; total internal reflection fluorescence microscopy; glycosaminoglycans; atomic force microscopy; binding kinetics; single particle tracking; herpes simplex virus;

    Sammanfattning : The herpes simplex virus is a widespread human pathogen, most commonly known for causing cold sores. Its infection cycle is initiated with the formation of multiple bonds between viral glycoproteins and cellular glycosaminoglycans, which are long polysaccharide chains found close to the cell surface. LÄS MER

  4. 4. Designing biosensor platforms to study glycosaminoglycan interactions

    Detta är en avhandling från Gothenburg : Chalmers tekniska högskola

    Författare :Noomi Altgärde; [2012]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; interaction studies; molecular immobilization; QCM-D; glycosaminoglycans; extracellular matrix;

    Sammanfattning : The importance of glycosaminoglycans (GAGs) has been highlighted in many areas of research during recent years. Not only are they important in providing structure and support to our tissues but they also function as interaction partners in the extracellular matrix and at the cell membrane. LÄS MER

  5. 5. The effect of hypoxia on macrophage proteoglycans: potential role in atherosclerosis

    Detta är en avhandling från Gothenburg : Chalmers tekniska högskola

    Författare :Annika Asplund; Göteborgs universitet.; Gothenburg University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; proteoglycans; glycosaminoglycans; macrophages; hypoxia; hypoxia-inducible transcription factor; LDL binding; cell motility;

    Sammanfattning : A critical step in the development of atherosclerotic lesions appears to be the retention of low density lipoproteins (LDL) in the arterial wall, mediated by negatively charged proteoglycans (PG). Retained LDL is susceptible to modification and uptake by resident macrophages that are found in hypoxic sites in atherosclerotic lesions (with oxygen levels below 1%). LÄS MER