Sökning: "gene expression analysis"

Visar resultat 31 - 35 av 1352 avhandlingar innehållade orden gene expression analysis.

  1. 31. Genetic Studies of Psoriasis and Psoriatic Arthritis

    Författare :Camilla Friberg; Göteborgs universitet; []
    Nyckelord :psoriasis; psoriatic arthritis; complex disease; autoimmune disease; linkage analysis; association analysis; PSOR5; 3q21; 5q31-32; SLC22A4; SLC22A5; CSTA; ZNF148; expression;

    Sammanfattning : Psoriasis and psoriatic arthritis are common chronic immune-mediated diseases of the skin and joints. Psoriasis affects approximately 2-3 % of the Caucasian population and about 30 % of all psoriasis patients develop psoriatic arthritis. LÄS MER

  3. 32. Statistics in Gene Expression, Metabolomics, and Comparative Genomics in Evolution

    Författare :Alexandra Jauhiainen; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Gene Expression; Metabolomics; Data Integration; Comparative genomics; Gene Expression;

    Sammanfattning : This thesis contains four papers concerning (I) the evolutionary conservation of drug targets and its potential use in environmental risk assessments, (II) RNA degradation as a control mechanism during osmotic stress in the yeast S. cerevisiae, (III) the localization and effects of the gene DDIT3 encoding a key regulator of stress response, and (IV) the integration and analysis of transcriptional and metabolic data to identify active metabolic pathways. LÄS MER

  4. 33. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis

    Författare :Moataz Dowaidar; Ülo Langel; Sandrine Sagan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; magnetic nanoparticles; graphene oxide; autophagy; siRNA; SCO; QSAR; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. LÄS MER

  5. 34. Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened

    Författare :Renata Gustafsson; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cells; differentiation; FGF FGFR signalling; gene expression; microarray; Ened; early embryonic development;

    Sammanfattning : Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of blastocyst stage embryos, and upon differentiation into embryoid bodies (EBs) they recapitulate the genetic, cellular and morphological events occurring in early embryogenesis. Among several signalling pathways and inductive factors, the fibroblast growth factors (FGFs) and their receptors (FGFRs) have been shown to be important during early embryogenesis. LÄS MER

  7. 35. Clinical and Experimental Studies in Chronic Myeloid Leukemia : Studies of Treatment Outcome, In Vitro Cellular Drug Resistance and Gene Expression

    Författare :Ulla Olsson-Strömberg; Bengt Simonsson; Elin Lindhagen; Gisela Barbany; Johan Richter; Uppsala universitet; []
    Nyckelord :Medicine; chronic myeloid leukemia; adult; stem cell transplantation; mobilization of Ph-negative stem cells; in vitro assay; imatinib; gene expression; Medicin;

    Sammanfattning : The aims of the studies described in the thesis were to investigate different treatment strategies in chronic myeloid leukemia (CML) patients. Furthermore, activity of imatinib was investigated by in vitro cytotoxicity assay, and the gene expression pattern in interferon treated patients. LÄS MER