Sökning: "gene expression analysis"

Visar resultat 11 - 15 av 1352 avhandlingar innehållade orden gene expression analysis.

1. 11. Weighted Analysis of Microarray Experiments

   Författare :Anders Sjögren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA microarray; differential expression; gene expression; quality control QC ; quality assurance QA ; quality assessment; generalised linear model; empirical Bayes; weighted moderated statistic; invalid p-value; heteroscedasticity; WAME; heteroscedasticity;

   Sammanfattning : DNA microarrays are strikingly efficient tools for analysing gene expression for large sets of genes simultaneously. The aim is often to identify genes which are differentially expressed between some studied conditions, thereby gaining insight into which cellular mechanisms are differently active between the conditions. LÄS MER

3. 12. Deconvolution of Spatial Gene Expression in Cancer

   Författare :Linnea Stenbeck; Stefania Giacomello; Joakim Lundeberg; Vicent Pelechano; KTH; []
   Nyckelord :Spatial transcriptomics; Gene expression; Cancer; Bioteknologi; Biotechnology;

   Sammanfattning : Cancer is the second leading cause of death in the world, claiming nearly 10 million lives in 2020 alone. One of the main issues in anti-cancer treatment is the heterogeneity of the tumor microenvironment (TME). The TME consists of different cells that are critical for cancer development. LÄS MER

4. 13. Computational methods for analysis of spatial transcriptomics data : An exploration of the spatial gene expression landscape

   Författare :Alma Andersson; Joakim Lundeberg; Omer Bayraktar; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; spatial transcriptomics; machine learning; data analysis; RNA-seq; probabilistic; statistical; models; Biotechnology; Bioteknologi;

   Sammanfattning : Transcriptomics techniques, whether in the form of bulk, single cell/nuclei, or spatial methods have fueled a substantial expansion of our knowledge about the biological systems within and around us. In addition, the rate of innovation has accelerated over the last decade, resulting in a multitude of technological advances and new methods for generation of transcriptomics data. LÄS MER

5. 14. Genomic profiling of breast cancer by microarray-based technology and bioinformatics

   Författare :Johan Staaf; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Survival; Prognostic predictor; Gene Expression; ERBB2; HER2; Microarray; Copy Number Analysis; CGH; aCGH; Amplification; Gene expression analysis;

   Sammanfattning : Cancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to treatment. LÄS MER

7. 15. Gene Expression and DNA Methylation in Acute Lymphoblastic Leukemia

   Författare :Jessica Nordlund; Syvänen Ann-Christine; Xavier Estivill; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Digital gene expression; Allele-specific gene expression; DNA methylation; Epigenetics; Acute lymphoblastic leukemia; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Pediatric acute lymphoblastic leukemia (ALL) is the most common malignancy in children, which results from the malignant transformation of progenitor cells in the bone marrow into leukemic cells. The precise mechanisms for this transformation are not well defined, however recent studies suggest that aberrant regulation of gene expression or DNA methylation may play an important role. LÄS MER