Sökning: "fibril formation"

Visar resultat 26 - 30 av 94 avhandlingar innehållade orden fibril formation.

1. 26. Studies on chondroadherin-an extracellular matrix leucine-rich repeat protein

   Författare :Christina Wenglén; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; COMP; SLRP; ECM; collagen; cartilage; chondroadherin;

   Sammanfattning : This thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. LÄS MER

3. 27. Molecular mechanisms of amyloid self-regulation

   Författare :Michael Landreh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Amyloid is associated with both pathological protein deposits and the formation of functional protein structures. Therefore, several strategies have evolved to control the formation or inhibition of amyloid in vivo. LÄS MER

4. 28. The role of leucine-rich repeat glycoproteins/proteoglycans in the assembly of collagen matrices

   Författare :Liz Svensson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; decorin; Collagen; fibromodulin; extracellular matrix; lumican; collagen fibrillogenesis; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Biokemi; Metabolism;

   Sammanfattning : The properties of different connective tissues depend on the synthesis and assembly of macromolecular structures composed of collagen and other extracellular matrix components. Mechanisms modulating these events play important roles in the formation of a functional tissue. LÄS MER

5. 29. Amyloid Proteins in Neurodegenerative Disease – Role of Extrinsic Modifiers

   Författare :Nima Sasanian; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Sammanfattning : ABSTRACT Self-assembly of disease-associated proteins into fibrillar homopolymers, so-called “amyloid fibrils” is a pathological hallmark of several debilitating human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). AD and PD are associated with the formation of amyloid fibrils from the proteins amyloid-β (Aβ) and α-syn (α-syn), in the extracellular and intracellular space, respectively. LÄS MER

7. 30. alpha-synuclein: amyloid fibrils and interactions with lipid membranes

   Författare :Marija Dubackic; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alpha-synuclein; model lipid membranes; amyloid fibrils; Parkinson s disease; Lewy bodies; SANS; SAXS;

   Sammanfattning : The second most common neurodegenerative disease, Parkinson’s disease, is linked with an amyloid forming protein, alpha-synuclein. Hallmarks of Parkinson’s disease are progressive loss of dopaminergic neurons and accumulation of intraneuronal inclusions termed Lewy bodies. LÄS MER