Sökning: "alpha-synuclein"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet alpha-synuclein.

  1. 1. Alpha-Synuclein Oligomers Cellular Mechanisms and Aspects of Antibody Treatment

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gabriel Gustafsson; Uppsala universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s Disease; Alpha-synuclein; Aggregation; Oligomers; Monoclonal Antibody; Glia; Astrocyte; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. LÄS MER

  2. 2. Characterization of Physiological and Pathological Alpha-Synuclein Implications for Parkinson’s Disease and Related Disorders

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Leire Almandoz Gil; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Alpha-synuclein; Aggregation; Parkinson’s disease; Dementia with Lewy bodies; Oxidative stress; Antibodies; Synapses; SNARE; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. LÄS MER

  3. 3. GDNF and alpha-synuclein in nigrostriatal degeneration

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Maria Chermenina; Umeå universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; GDNF; ventral mesencephalon; lateral ganglionic eminence; alpha-synuclein; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Parkinson’s disease is a common neurological disorder with a complex etiology. The disease is characterized by a progressive loss of dopaminergic cells in the substantia nigra, which leads to motor function and sometimes cognitive function disabilities. LÄS MER

  4. 4. Pathogenic effects of alpha-synuclein: modifications and toxicity

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Natalie Landeck; Lund University.; Lunds universitet.; [2016]
    Nyckelord :Parkinson s disease; adeno-associated viral vector; animal models; alpha-synuclein; substantia nigra; dopaminergic neurons; phosphorylation; aggregation; toxicity;

    Sammanfattning : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. LÄS MER

  5. 5. Investigation of alpha-synuclein pathology in Parkinson's disease

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Wen Li; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; alpha-synuclein; mitochondria; propagation;

    Sammanfattning : AbstractParkinson's disease (PD) is one of the most common neurodegenerative diseases in humans. It is a slowly progressing neurological disorder exhibiting major symptoms including resting tremor, rigidity, bradykinesia and postural instability. LÄS MER