Sökning: "chondroadherin"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet chondroadherin.

  1. 1. Studies on chondroadherin-an extracellular matrix leucine-rich repeat protein

    Författare :Christina Wenglén; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; COMP; SLRP; ECM; collagen; cartilage; chondroadherin;

    Sammanfattning : This thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. LÄS MER

  3. 2. Complex Formation in the Extra Cellular Matrix- Structural Study of CTLD of Agrrecan, Tenascin-R and Chondroadherin

    Författare :Anna Pramhed; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aggrecan; ECM; fibulin; structure; tenascin; CHAD; chondroadherin; X-ray; crystallography; calcium; CTLD; C-type lectin; fibronectin; FnIII; LRR; epidermal growth factor; leucine-rich repeat; matrix; EGF; cbEGF;

    Sammanfattning : The cells of higher organisms exist in a complex protein network, the extracellular matrix (ECM), which has a wide variety of different components such as glycoproteins, proteoglycans and carbohydrates. As well as being the physical scaffold on which the cells are dependent for their positioning and mobility, the ECM exercises control over the cells, and changes in the matrix will affect the adhesion, proliferation and differentiation properties of these cells. LÄS MER

  4. 3. Cartilage homeostasis: Modulation of cells and extracelllar matrix assembly

    Författare :Anna Johnson; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; COMP; Perlecan; chondroadherin; cartilage; ECM; Medicin människa och djur ;

    Sammanfattning : The cartilage extracellular matrix consists of the collagen network which enmeshes the large aggregating proteoglycan, aggrecan. Accessory molecules regulate the formation and maintenance of these structures. This thesis studies aspects of cartilage assembly during development and its degradation in disease, focusing on the collagen network. LÄS MER

  5. 4. Expression and localization of extracellular matrix proteins in rat skeletal development

    Författare :Zhenxin Shen; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; BSP and osteoadherin.; COMP; chondroadherin; rat femoral head; Bone; extracellular matrix protein; cartilage; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

    Sammanfattning : Several novel matrix molecules of cartilage and bone have recently been identified and characterized. Studies of the maturation of the femoral head give clues as to the function of the novel matrix proteins. LÄS MER

  7. 5. Chondrocyte-matrix interactions: with emphasis on the collagen binding integrin a10ß1

    Författare :Lisbet Camper; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; Skeleton; chondrocyte; integrin; cartilage; chondroadherin; collagen; Biochemistry; metabolism; Biokemi; reumatologi; muskelsystem; Skelett; rheumatology locomotion;

    Sammanfattning : The work in this thesis has been focused on chondrocyte integrins and their interaction with the matrix proteins chondroadherin (CHAD) and collagen type II (CII). Affinity purification of CHAD-binding proteins from chondrocyte lysate, followed by immunoprecipitation of EDTA-eluted material identified alpha2beta1 as a CHAD-binding integrin. LÄS MER