Sökning: "fibril formation"
Visar resultat 6 - 10 av 94 avhandlingar innehållade orden fibril formation.
6. Secondary Nucleation in Amyloid Formation
Sammanfattning : Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. LÄS MER
7. Apolipoprotein A-IV and Transthyretin in Swedish Forms of Systemic Amyloidosis
Sammanfattning : Over 20 different plasma proteins have been shown to have the capacity to undergo conformational changes and self-assemble into highly stable and insoluble amyloid fibrils. One, transthyretin (TTR), consists of 127 amino acid residues arranged in eight β-strands (named A to H) and is involved in two different clinical forms of amyloidosis. LÄS MER
8. α-Synuclein Fibril Formation and the Effects of Lipid Membranes
Sammanfattning : Amyloid protein aggregation results in major disturbances of cellular processes in humans. The most common amyloid-related disorders are Alzheimer´s disease and Parkinson´s disease. Parkinson´s disease is charaterized by the formation of protein-rich aggregates that are deposited in neurons, termed Lewy bodies and Lewy neurites. LÄS MER
9. Palmitoylation and amyloid fibril formation of lung surfactant protein C
Sammanfattning : Lung surfactant is a mixture of lipids and a few proteins, of which surfactant proteins (SP)-B and SP-C are lipophilic. Surfactant is essential for the reduction of surface tension at the alveolar air/liquid interface. LÄS MER
10. Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation
Sammanfattning : Alzheimer's disease is a progressive neurodegenerative disease, mostly affecting elderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloid ß-peptide (Aß) in the parenchyma and blood vessels of the brain is a central event. LÄS MER