Sökning: "fibril formation"

Visar resultat 21 - 25 av 94 avhandlingar innehållade orden fibril formation.

  1. 21. Kinetic stabilization of transthyretin and its role as an inhibitor of Aβ amyloid formation

    Författare :Lina Nilsson; Anders Olofsson; Elisabeth Sauer-Eriksson; Gunilla Westermark; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amyloid; transthyretin; amyloid beta; kinetic stabilizer; biokemi; Biochemistry;

    Sammanfattning : Amyloid formation occurs when normally soluble proteins and peptides misfold and aggregate into intractable threadlike structures called fibrils. There are currently more than 30 proteins associated with this aberrant structure, including the Aβ peptide in Alzheimer’s disease (AD) and transthyretin (TTR) in TTR amyloidosis. LÄS MER

  3. 22. Biophysical studies on aggregation processes and amyloid fibrils with focus on Alzheimer's disease

    Författare :Niklas Bark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fluorescence correlation spectroscopy; amyloid fibril formation; Alzheimer s disease;

    Sammanfattning : Alzheimer's disease (AD) is a fatal neurodegenerative disease, and is the most common form of dementia, affecting 1-2% of the population in industrialized countries. It is believed that intermediate species formed during amyloid Bpeptide (AB) polymerization play a key role in the pathogenesis of AD, but it is not known how such toxic effects are exerted. LÄS MER

  4. 23. Fluorescent Probes and Protein Misfolding: Methods and Applications

    Författare :Irem Nasir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein misfolding; fluorophores; filter-trap; site-specific fluorophore labeling; amyloid-beta; microscopic rate constants; solvatochromic probes; alpha-synuclein; lipid vesicles; nanoparticles; protein adsorption;

    Sammanfattning : Protein misfolding is a frequently occurring event in living cells and without the quality control, the consequences are disasterous. In this thesis, we studied protein misfolding in vitro by employing a variety of fluorophores, to either detect the highly ordered aggregates of intrinsically disordered proteins/peptides or slight misfolding of a natively folded protein. LÄS MER

  5. 24. Basement membrane components in the chondrocyte extracellular matrix

    Författare :Alexander Kvist; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skelett; rheumatology locomotion; nidogen; chondroitin sulfate; collagen assembly; Skeleton; muscle system; type IV collagen; laminin; perlecan; basement membranes; ECM; chondrcytes; muskelsystem; reumatologi;

    Sammanfattning : The extracellular matrix (ECM) is a network of macromolecules which, together with cells, forms the various tissues of all metazoan organisms. Cartilage, in contrast to most other tissues, contains relatively few cells in proportion to the volume occupied by ECM. LÄS MER

  7. 25. Islet Amyloid Polypeptide: Interaction with Amyloid Beta, Alpha-Synuclein and BRICHOS

    Författare :Ye Wang; Gunilla Westermark; Ludmilla Morozova-Roche; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; alpha-synuclein; Bri2 BRICHOS; luminescent conjugated oligothiophenes; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning :  Amyloid, the congophilic deposits of misfolded protein, are pathological hallmarks of many common diseases, among others, Alzheimer’s disease (AD), Parkinson’s disease (PD), and type 2 diabetes (T2D). Amyloid beta (Aβ) forms senile plaques in AD, alpha-synuclein (aSyn) forms Lewy bodies and Lewy neurites in PD, islet amyloid polypeptide (IAPP) forms islet amyloid in T2D. LÄS MER