Sökning: "amyloid fibrils"

Visar resultat 1 - 5 av 83 avhandlingar innehållade orden amyloid fibrils.

  1. 1. The amyloid structure, properties and application

    Detta är en avhandling från Umeå : Medicinsk kemi och biofysik

    Författare :Mantas Malisauskas; Umeå universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; oligomers; AFM; cytotoxicity; biotemplating; lysozyme; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Sammanfattning : Protein aggregation, leading to the formation and depositions of amyloids, is a cause for a number of diseases such as Alzheimer’s and Creutzfeld-Jacob’s disease, systemic amyloidoses, type II diabetes and others . More than 20 proteins are associated with protein misfolding diseases and even a larger number of proteins can self-assemble into amyloid in vitro. LÄS MER

  2. 2. Proislet Amyloid Polypeptide (proIAPP) Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Johan F. Paulsson; Linköpings universitet.; Linköpings universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biosynthesis amyloid; Genetics amyloid; Metabolism amyloid; Islets of Langerhans; Proprotein convertases; Posttranslation protein processing; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi;

    Sammanfattning : Amyloid is defined as extracellular protein aggregates with a characteristic fibrillar ultra-structure, Congo red affinity and a unique x-ray diffraction pattern. At present, 25 different human amyloid fibril proteins have been identified, and amyloid aggregation is associated with pathological manifestations such as Alzheimer’s disease, spongiform encephalopathy and type 2 diabetes. LÄS MER

  3. 3. Medin amyloid - a matter close to the heart Studies on medin amyloid formation and involvement in aortic pathology

    Detta är en avhandling från Uppsala : Universitetsbiblioteket

    Författare :Annika Larsson; Uppsala universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AA amyloidosis; aging; amyloid; aneurysm; arterial media; dissection; elastin; medin amyloid; lactadherin; thoracic aorta; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi;

    Sammanfattning : Amyloidoses are a group of protein misfolding diseases characterized by deposits of insoluble fibrillar protein aggregates. Medin amyloid, which is the focus of this thesis, appears in the media of the thoracic aorta in nearly all individuals over 50 years. LÄS MER

  4. 4. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Marie Oskarsson; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; type 2 diabetes; Alzheimer disease; BRICHOS; heparan sulfate; islet amyloid; amyloid plaques; seeding; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. LÄS MER

  5. 5. Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires

    Detta är en avhandling från Institutionen för fysik, kemi och biologi

    Författare :Anna Herland; Linköpings universitet.; Linköpings universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Conjugated Polymers; Amyloid Fibrils; Nanowires; Self-Assembly; Sensor; Amyloid Detection; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik;

    Sammanfattning : The research field of conjugated polymers has grown due to the optical and electronic properties of the material, useful in applications such as solar cells and printed electronics, but also in biosensors and for interactions with biomolecules. In this thesis conjugated polymers have been used in two related topics; to detect conformational changes in proteins and to assemble the polymers with biomolecules into nanowires. LÄS MER