Sökning: "fibril formation"

Visar resultat 16 - 20 av 94 avhandlingar innehållade orden fibril formation.

1. 16. Self-assembly of amyloid-β peptides in the presence of metal ions and interacting molecules – a detour of amyloid building blocks

   Författare :Cecilia Mörman; Astrid Gräslund; Daniel Otzen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biophysics; Alzheimer’s disease; protein aggregation; amyloid formation; amyloid-β peptide; aggregation kinetics; interactions; metal ions; designed peptide constructs; Tau protein; NMR; circular dichroism; fluorescence spectroscopy; Biophysics; biofysik;

   Sammanfattning : Misfolding of proteins into amyloid structures is implicated as a pathological feature in several neurodegenerative diseases and the molecular causes are still unclear. One typical characteristic of Alzheimer’s disease is self-assembly and accumulation of soluble amyloid-β (Aβ) peptides into insoluble fibrils and plaques. LÄS MER

3. 17. Cellular Uptake of Amyloid Forming Proteins Related to Neurodegenerative Disease

   Författare :Emelie Vilhelmsson Wesén; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aβ 1-40 ; flow cytometry; confocal microscopy; SH-SY5Y; fluorescence; Aβ 1-42 ; Alzheimer’s disease; amyloid fibril; α-synuclein; amyloid-β;

   Sammanfattning : Aggregation and deposition of disease-associated protein is a pathological hallmark of several human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). These diseases are characterized by the formation of amyloid-β (Aβ) and α-synuclein (α-syn) amyloid fibrils, in extracellular and intracellular locations, respectively. LÄS MER

4. 18. Mechanistic and morphological studies of Aβ amyloid formation using surface plasmon resonance

   Författare :Md Tohidul Islam; Anders Olofsson; Ludmilla Morozova-Roche; Vytautas Smirnovas; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; medicinal chemistry; läkemedelskemi; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and apart from the individual suffering AD also causes a large economic burden for society. AD is associated with progressive neurodegeneration and atrophy of the brain. LÄS MER

5. 19. Development of the Amyloid Fibril Characterisation Toolbox - New use for old dyes

   Författare :David Lindberg; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Amyloid-β; Thioflavin-T; Fluorescence spectroscopy; YOYO-1; Amyloid fibrils; Linear dichroism; Alzheimer’s disease;

   Sammanfattning : Amyloid fibrils are self-assembled protein homopolymers that playcentral roles in the pathology of several human diseases, most notably in progressiveneurodegenerative diseases such as Alzheimer’s disease (AD). In AD, fibrils areformed by the amyloid-β (Aβ) peptide, an enzymatic cleavage product that is naturallyproduced in human brain tissue. LÄS MER

7. 20. Flame-Retardant Cellulose Fibre/Fibril Based Materials via Layer-by-Layer Technique

   Författare :Oruc Koklukaya; Lars Wågberg; Gero Decher; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Flame-retardant; cellulose fibre; cellulose nanfibril; layer-by-layer technique; Fiber- och polymervetenskap; Fibre and Polymer Science;

   Sammanfattning : According to an analysis conducted by the Swedish Chemicals Inspectorate in 2006, the approximate numbers of fire injuries per year in Sweden are 100 deaths, 700 major and 700 minor injuries.1 Observations also show that there has been an increase in the number of house fires during recent years. LÄS MER