Sökning: "försämring"

Visar resultat 26 - 30 av 91 avhandlingar innehållade ordet försämring.

1. 26. Multiplexed antibody-based protein profiling in the pursuit of CSF biomarkers for neurodegenerative diseases

   Författare :Sofia Bergström; Peter Nilsson; Anna Månberg; Markus Otto; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Protein profiling; suspension bead array; cerebrospinal fluid; biomarker discovery; proteomics; Bioteknologi; Biotechnology;

   Sammanfattning : There is a desire for a transition from generic treatments designed for the average patient, towards more individual-based precision medicine. An increased knowledge about disease pathophysiology on a molecular level would be beneficial for this transition. LÄS MER

3. 27. Phase separation in duplex stainless steel: characterization and mitigation

   Författare :Jianling Liu; Peter Hedström; Joakim Odqvist; Wangzhong Mu; Aniruddha Biswas; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; duplex stainless steel; 475 °C embrittlement; phase separation; small-angle neutron scattering; mechanical properties; alloying elements; cooling rate; magnetic field; Materials Science and Engineering; Teknisk materialvetenskap;

   Sammanfattning : Duplex stainless steel (DSS) is a category of widely used stainlesssteel, which are strategically important in a variety of applications such asin the food industry, chemical engineering plants and nuclear power plants,due to their attractive combination of mechanical properties and corrosionresistance. However, these steel grades are sensitive to the so-called ‘475°Cembrittlement’, because of a phase separation (PS) phenomenon in theferrite phase, which decomposes into Fe-rich ferrite (α) and Cr-rich ferrite(α'), when exposed to temperatures within the miscibility gap. LÄS MER

4. 28. Hematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden

   Författare :Christina Zjukovskaja; Joachim Burman; Kim Kultima; Susanna Brauner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AHSCT; HSCT; hematopoietic stem cell transplantation; multiple sclerosis; RRMS; inflammation; biomarkers; АТГСК; ТГСК; Трансплантация гемопоэтических стволовых клеток; рассеянный склероз; воспаление; биомаркеры; AHSCT; HSCT; Hematopoetisk stamcellstransplantation; multipel skleros; RRMS; inflammation; biomarkör; Medicinsk vetenskap; Medical Science;

   Sammanfattning : This thesis investigated the efficacy and safety of autologous hematopoietic stem cell transplantation (AHSCT) as a treatment of multiple sclerosis. This thesis demonstrates that when compared to one of the most powerful disease-modifying drugs (DMDs), specifically alemtuzumab (ALZ), AHSCT is able to hold its ground. LÄS MER

5. 29. Vascular dementia - classification and clinical correlates

   Författare :Ulla Andin; Lund Psykiatri; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; psychosomatics; Psychiatry; clinical psychology; Medicine human and vertebrates ; falls; clinical course; hypertension; orthostatic hypotension; dizziness; cerebrovascular disease; Alzheimer?s disease; Neuropathological subgroups; cardiovascular disease; Psykiatri; klinisk psykologi; psykosomatik; Medicin människa och djur ;

   Sammanfattning : During the period (1976-1995) a total of 175 consecutive patients (m 88/f 87) with neuropathologically verified vascular dementia (VaD) were examined. 22 patients with pure Alzheimer's Disease (AD) were also studied. All patients were diagnosed and followed at the Department of Psychogeriatrics (Lund University Hospital). LÄS MER

7. 30. Astrocytes as Cellular Vehicles in Ex Vivo Gene Therapy Studies to the Rat Brain

   Författare :Cecilia Ericson; CNS Genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Lentivirus; Transplantation; CNS; Astrocytes;

   Sammanfattning : Neurodegenerative disorders are characterized by a progressive cell-death in the brain, and loss of different functions in the patient. Today, there are no cures for any of the various diseases. Parkinson's disease is a neurodegenerative disorder with a prevalence of 0. LÄS MER