Sökning: "Kim Kultima"
Hittade 5 avhandlingar innehållade orden Kim Kultima.
1. Transcriptomics and Proteomics Applied to Developmental Toxicology
Sammanfattning : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. LÄS MER
2. Proteomics Studies of Subjects with Alzheimer’s Disease and Chronic Pain
Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease and the major cause of dementia, affecting more than 50 million people worldwide. Chronic pain is long-lasting, persistent pain that affects more than 1.5 billion of the world population. LÄS MER
3. Peripheral apolipoprotein E and its emerging role in neurodegenerative disease
Sammanfattning : The human apolipoprotein E gene (APOE) is polymorphic and coding for three common alleles; ε2, ε3, and ε4. Carriers of the ε4 allele are at a higher risk of developing sporadic late-onset Alzheimer’s Disease (AD). This association appears to be influenced by inherited traits, race, and sex. LÄS MER
4. Towards an Earlier Detection of Progressive Multiple Sclerosis using Metabolomics and Machine Learning
Sammanfattning : Decision-making guided by advanced analytics is becoming increasingly common in many fields. Implementing computationally driven healthcare solutions does, however, pose ethical dilemmas as it involves human health. LÄS MER
5. Hematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden
Sammanfattning : This thesis investigated the efficacy and safety of autologous hematopoietic stem cell transplantation (AHSCT) as a treatment of multiple sclerosis. This thesis demonstrates that when compared to one of the most powerful disease-modifying drugs (DMDs), specifically alemtuzumab (ALZ), AHSCT is able to hold its ground. LÄS MER