Sökning: "blood-brain barrier"

Visar resultat 21 - 25 av 190 avhandlingar innehållade orden blood-brain barrier.

1. 21. Cell-penetrating peptide based nanocomplexes for oligonucleotide delivery

   Författare :Jakob Regberg; Ülo Langel; Arwyn Tomos Jones; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; oligonucleotides; gene therapy; drug delivery; scavenger receptors; blood-brain barrier; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Oligonucleotide-based drugs hold great promise for the treatment of many types of diseases, ranging from genetic disorders to viral infections and cancer. The problem is that efficient delivery across the cell membrane is required for oligonucleotides to have their desired effect. Cell-penetrating peptides (CPPs) provide a solution to this problem. LÄS MER

3. 22. Microdialysis and Intensive Care. Clinical and experimental studies

   Författare :Per Ederoth; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology; traumatic brain injury; glucose; glycerol; lipolysis; epidural; postoperative analgesia; experimental pancreatitis; human; blood-brain barrier; morphine; pharmacokinetics; Microdialysis; intensive care; Anestesiologi; intensivvård;

   Sammanfattning : Microdialysis was used to monitor local concentrations of energy metabolites in different organs, and to study the pharmacokinetics of morphine over the blood-brain barrier in intact and injured brain tissue in conditions treated in the Intensive Care Unit. After major abdominal or thoracoabdominal surgery, postoperative thoracic epidural analgesia resulted in higher glycerol concentrations in the deltoid subcutaneous adipose tissue, implying increased lipolysis, on the third postoperative day as compared to intravenous infusion of morphine, possibly due to a locally increased sympathetic tone. LÄS MER

4. 23. On cerebrospinal fluid markers of HIV-1 infection

   Författare :Lars-Magnus Andersson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; cerebrospinal fluid; AIDS dementia complex; ganglioside GD3; Tau proteins; neopterin; HIV-1 RNA; blood-brain barrier; albumin ratio; cultivation;

   Sammanfattning : HIV-1 infects the central nervous system early in the course of infection and neurological complications are common in HIV-1-infected individuals. Approximately 20% of individuals with acquired immunodeficiency syndrome (AIDS) not treated with antiretroviral therapy develop a subcortical dementia, AIDS dementia complex (ADC). LÄS MER

5. 24. Olfactory Transfer of Analgesic Drugs After Nasal Administration

   Författare :Ulrika Espefält Westin; Erik Björk; Eva Brittebo; Margareta Hammarlund-Udenaes; Paolo Colombo; Uppsala universitet; []
   Nyckelord :Pharmaceutics; Nasal administration; Olfactory transfer; Olfactory pathways; Central nervous system; Blood-brain barrier; Nasal respiratory mucosa; Olfactory mucosa; Olfactory bulb; Horizontal Ussing chamber; Morphine; Dihydroergotamine; Rat; Mouse; Swine; Autoradiography; Viability; Powder formulations; Galenisk farmaci;

   Sammanfattning : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. LÄS MER

7. 25. Cardiac surgery and the brain - studies on cerebral blood flow autoregulation and mechanisms of cerebral injury

   Författare :Björn Reinsfelt; Göteborgs universitet; []
   Nyckelord :Cardiac surgery; cerrebral dysfunction; cardiopulmonary bypass; anaesthetics; aortic valve replacement; transcranial Doppler; cerebraospinal fluid; blood-brain barrier;

   Sammanfattning : Cardiac surgery and the brain - studies on cerebral blood flow autoregulation and mechanisms of cerebral injury Björn Reinsfelt Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Sweden Abstract Cerebral dysfunction (CD) occurs frequently after cardiac surgery with cardiopulmonary bypass (CPB). The main causes of CD are thought to be cerebral hypoperfusion, cerebral microembolisation , cerebral inflammation or disruption of the blood brain barrier (BBB). LÄS MER