Sökning: "Pharmaceutics"

Visar resultat 1 - 5 av 62 avhandlingar innehållade ordet Pharmaceutics.

  1. 1. Mechanical strength of pharmaceutical compacts : Importance of material characteristics, particle characteristics and compaction pressure on interparticulate bonding structure

    Författare :Åsa Adolfsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Factors considered important for the interparticulate bonding structure and mechanical strength of pharmaceutical compacts were studied in this thesis.Fractures appear to propagate mainly around rather than through grains during strength testing. LÄS MER

  2. 2. In vitro and in silico prediction of drug-drug interactions with transport proteins

    Författare :Gustav Ahlin; Per Artursson; Christel Bergström; Johan Karlsson; Jörg König; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; Pharmaceutics; Galenisk farmaci; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics; Biopharmaceutics; biofarmaci;

    Sammanfattning : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. LÄS MER

  3. 3. Pharmaceutical cocrystals : formation mechanisms, solubility behaviour and solid-state properties

    Författare :Amjad Alhalaweh; Luleå tekniska universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocrystal; formation; solubility; pH; dissolution; surface properties; Pharmaceutics; Pharmacy; Farmaci; Health Science; Hälsovetenskap;

    Sammanfattning : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. LÄS MER

  4. 4. Engineering of Pharmaceutical Particles : Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process

    Författare :Jonas Berggren; Göran Alderborn; Graham Buckton; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; particle engineering; microcrystalline cellulose pellets; intragranular porosity; convective drying; tabletting behaviour; spray-dried composite particles; amorphous lactose; PVP; heat and moisture-induced crystallisation; glass transition temperature; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. LÄS MER

  5. 5. Computational and Experimental Models for the Prediction of Intestinal Drug Solubility and Absorption

    Författare :Christel A. S. Bergström; Per Artursson; Han van de Waterbeemd; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; aqueous drug solubility; melting point; intestinal drug permeability; pH-dependent solubility; multivariate data analysis; molecular descriptors; molecular surface area; in silico modeling; drug absorption; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : New effective experimental techniques in medicinal chemistry and pharmacology have resulted in a vast increase in the number of pharmacologically interesting compounds. However, the number of new drugs undergoing clinical trial has not augmented at the same pace, which in part has been attributed to poor absorption of the compounds. LÄS MER