Sökning: "Powder formulations"
Visar resultat 1 - 5 av 14 avhandlingar innehållade orden Powder formulations.
1. Olfactory Transfer of Analgesic Drugs After Nasal Administration
Sammanfattning : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. LÄS MER
2. Studies on a Novel Powder Formulation for Nasal Drug Delivery
Sammanfattning : Nasal administration has potential for the treatment of indications requiring a fast onset of effect or for drugs with low oral bioavailability. Liquid nasal sprays are relatively common, but can be associated with suboptimal absorption from the nasal cavity; this thesis shows that nasal absorption can be significantly enhanced with a dry powder formulation. LÄS MER
3. Novel injectable calcium sulfate depot formulations for local cancer treatment
Sammanfattning : In the present thesis, a novel drug delivery technology named NanoZolid® based on hydrating inorganic calcium sulfate, is investigated. NanoZolid is injected as a liquid suspension of calcium sulfate, which solidifies in vivo by hydration forming a biocompatible and bioresorbable depot that slowly dissolves and releases the active substance. LÄS MER
4. On computational modeling of sintering based on homogenization
Sammanfattning : Liquid-phase sintering is the process where a precompacted powder, “green body”, is heatedto the point where (a part of) the solid material melts, and the specimen shrinks while keeping(almost) net shape. In the case of hardmetal, the microstructure is defined by WC-Co-particleswith large pores, whereby molten Co represents the liquid phase. LÄS MER
5. Insulin Polymorphism Crystallographic Characterization of Insulin Microcrystals
Sammanfattning : Insulin is a protein needed for the uptake of glucose from the circulating blood. In absence of sufficiently high insulin levels in the body or when the cells have a reduced sensitivity for insulin a disease state referred to as diabetes occurs. Treatment of diabetes generally requires daily injections of exogenous insulin. LÄS MER