Sökning: "HIV-1"

Visar resultat 1 - 5 av 299 avhandlingar innehållade ordet HIV-1.

1. 1. On cerebrospinal fluid markers of HIV-1 infection

   Författare :Lars-Magnus Andersson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; cerebrospinal fluid; AIDS dementia complex; ganglioside GD3; Tau proteins; neopterin; HIV-1 RNA; blood-brain barrier; albumin ratio; cultivation;

   Sammanfattning : HIV-1 infects the central nervous system early in the course of infection and neurological complications are common in HIV-1-infected individuals. Approximately 20% of individuals with acquired immunodeficiency syndrome (AIDS) not treated with antiretroviral therapy develop a subcortical dementia, AIDS dementia complex (ADC). LÄS MER

3. 2. Development of novel molecular and microfluidics tools for identification and characterization of latent HIV-1 reservoir

   Författare :Wang Zhang; Aman Russom; Ujjwal Neogi; Afshin Ahmadian; Utkan Demirci; KTH; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; Latent HIV-1 reservoir; HIV-1 characterization; Microfludics; Molecular detection; Medical Technology; Medicinsk teknologi;

   Sammanfattning : The existence of latent HIV-1 reservoir (LR) in all HIV-1 infected patients serves as a major obstacle to completely cure HIV-1 infection. However, up to now there is still no available assay that provides an accurate measurement of the reservoir size. LÄS MER

4. 3. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

   Författare :Sahra Abdulle; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

   Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. LÄS MER

5. 4. Antiretroviral treatment of HIV-1 in the central nervous system

   Författare :Aylin Yilmaz; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

   Sammanfattning : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. LÄS MER

7. 5. Structure-Assisted Design of Drugs Towards HIV-1 and Malaria Targets : Applied on Reverse Transcriptase and Protease from HIV-1 and Plasmepsin II from Plasmodium falciparum

   Författare :Jimmy Lindberg; Torsten Unge; Alexander Wlodawer; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; X-ray crystallography; Drug design; HIV-1; Malaria; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Sammanfattning : Globally of today, acquired immunodeficiency syndrome (AIDS) and malaria are two of the most threatening diseases known to mankind. The World Health Organization estimated that AIDS and malaria together claimed nearly 4 million lives in 2003 and many more were infected by the causative agent human immunodeficiency virus (HIV) and the Plasmodium falciparum (P. LÄS MER