Sökning: "Olfactory pathways"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Olfactory pathways.

  1. 1. Olfactory Transfer of Analgesic Drugs After Nasal Administration

    Författare :Ulrika Espefält Westin; Erik Björk; Eva Brittebo; Margareta Hammarlund-Udenaes; Paolo Colombo; Uppsala universitet; []
    Nyckelord :Pharmaceutics; Nasal administration; Olfactory transfer; Olfactory pathways; Central nervous system; Blood-brain barrier; Nasal respiratory mucosa; Olfactory mucosa; Olfactory bulb; Horizontal Ussing chamber; Morphine; Dihydroergotamine; Rat; Mouse; Swine; Autoradiography; Viability; Powder formulations; Galenisk farmaci;

    Sammanfattning : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. LÄS MER

  3. 2. Drugs in the olfactory pathways: bioactivation, toxicity and transfer to the brain

    Författare :Elena Piras; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. Experimental studies on the sources, pathways and targets for volume transmission in the rat brain

    Författare :Anders Jansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :volume transmission; extracellular space; monoamines; Dl D2 receptors; 5HT2A receptors; nitric oxide; interleukin-1ß; cholecystokinin; galanin;

    Sammanfattning : Volume transmission has been defined as the three-dimensional diffusion or convection of transmitters in the extracellular space (ECS) and cerebrospinal fluid (CSF) over a larger distance than the synaptic cleft. The regional localization of dopamine (DA) nerve terminals and dopamine Dl and D2 receptors in nucleus accumbens were studied in detail using double immuno-labelling. LÄS MER

  5. 4. Neurotropic influenza A virus infection in the mouse brain : targeting, persistence and functional effects

    Författare :Fredrik Aronsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Influenza A virus; nervous system;

    Sammanfattning : Viral infections of the central nervous system have been associated with sensory, motor and behavioral disturbances both in humans and in animals. An example of this is influenza A virus infection that causes acute respiratory diseases, which occasionally are followed by complications from the central nervous system. LÄS MER

  7. 5. On large-scale neural simulations and applications in neuroinformatics

    Författare :Simon Benjaminsson; Anders Lansner; Marc-Oliver Gewaltig; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis consists of three parts related to the in silico study of the brain: technologies for large-scale neural simulations, neural algorithms and models and applications in large-scale data analysis in neuroinformatics. All parts rely on the use of supercomputers. LÄS MER