Sökning: "bisphosphonate"

Visar resultat 16 - 20 av 33 avhandlingar innehållade ordet bisphosphonate.

  1. 16. Following the mevalonate pathway to bone heal alley

    Författare :Björn Skoglund; Lars Nordsletten; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Bone screws; coated materials; biocompatible; chemistry; diphosphonates; pharmacology; Equipment failure analysis methods; Femoral fractures; drug therapy; fracture fixation; instrumentation; Fracture fixation; fracture healing; drug effects; simvastatin; tibial fractures; physiopathologyial fractures; surgery; Pharmaceutical chemistry; Farmaceutisk kemi; Other veterinary medicine; Övrig veterinärmedicin;

    Sammanfattning : The mevalonate pathway is an important biosynthetic pathway, found in all cells of virtually all known pro- as well as eukaryotic organisms. This thesis is an investigation into the use of two drugs, originally developed for different applications, but both affecting the mevalonate pathway, in to models of fracture repair. LÄS MER

  3. 17. Studies on hip fracture patients : effects of nutrition and rehabilitation

    Författare :Lena Flodin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hip fracture in the elderly is a serious condition associated with increased mortality. Survivors experience an increase in morbidity and disability that affect their independence and quality of life; the outcome for patients with dementia is particularly poor. LÄS MER

  4. 18. Evaluation of Functionalized Biopolymers as a Step Toward Targeted Therapy of Osteoporosis

    Författare :Sujit Kootala; Jöns Hilborn; Peter Thomsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Osteoporosis; Bone regeneration; Biomaterials; Hyaluronic acid; Bisphosphonates; Osteoclasts; Osteoblasts; Growth factors; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

    Sammanfattning : The work presented in this thesis focuses on the development of strategies and smart bioactive materials for the treatment of osteoporosis. High and low molecular weight soluble hyaluronic acid-bisphosphonate (HA-BP) derivatives were investigated for their ability to inhibit osteoclasts. LÄS MER

  5. 19. Uncemented femoral stems : studies on periprosthetic bone remodelling and prevention of bone loss in total hip arthroplasty

    Författare :Olof Sköldenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Introduction: Tapered uncemented femoral stems are popular implants in total hip arthroplasty (THA). They are easy to use and excellent long-term results have been reported for patients with primary osteoarthritis of the hip (OA). LÄS MER

  7. 20. Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors

    Författare :Ulrika Bäckman; Rolf Christofferson; Sven Påhlman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Angiogenesis; Neuroblastoma; MYCN; VEGF; SU11657; SU5416; TNP-470; zoledronic acid; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. LÄS MER