Sökning: "bisphosphonate"

Visar resultat 21 - 25 av 33 avhandlingar innehållade ordet bisphosphonate.

  1. 21. Multi-functional Hyaluronan Based Biomaterials for Biomedical Applications

    Författare :Xia Yang; Dmitri Ossipov; Matthias Lutolf; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hyaluronan; biomaterials functionalizations; biomedical applications; orthogonal chemistry; drug delivery; tissue regeneration; MRI; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : This thesis presents strategies for constructing multi-functional biomaterials based on hyaluronan (HA) derivatives for various biomedical applications, such as drug delivery, tissue regeneration, and imaging biomaterials. The aim of this study is to improve the functionalities of HA biomaterials as well as simplify the preparation procedures. LÄS MER

  3. 22. The destiny of natural killer cells in the tumor microenvironment : to be suppressed or activated?

    Författare :Dhifaf Sarhan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the mid-70s, the term “natural” was used based on the functional properties of NK cells where they recognize and lyse certain tumor cells without requirement of prior immunization. Although NK cells are “natural” in their targeting of tumors, their responses in the tumor microenvironment have been very challenging to determine. LÄS MER

  4. 23. The fixation of joint prostheses. Aspects on mechanics and biology

    Författare :Ulrik Hansson; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; radiostereometry; histology; interface; micromotion; knee; joint replacement;

    Sammanfattning : Abstract: In the interface, between implant and bone or between the cement and bone, there will develop some amount of fibrous tissue. The synovial fluid, the synovium, the cartilage and the subchondral bone from the non-replaced knee compartment that had been exposed to wear particles were studied by histological analyses. LÄS MER

  5. 24. Metaphyseal Fracture Healing

    Författare :Olof Sandberg; Per Aspenberg; Aaron Schindeler; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Most of what is known about fracture healing comes from studies of shaft fractures in long bones. In contrast, patients more often have fractures closer to the ends (metaphyses). Here most bone tissue has a spongy, cancellous structure different from the compact bone of the shaft. LÄS MER

  7. 25. Pharmacological Modulation of Skeletal Homeostasis

    Författare :Niklas U. Andersson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Farmakologi; toxicology; farmakognosi; farmaci; toxikologi; pharmacy; pharmacognosy; Pharmacological sciences; peripheral quantitative computed tomography.; dual energy X-ray absorptiomenty; estrogen; parathyroid hormone; gastrectomy; alendronate; ovariectomy; Bone;

    Sammanfattning : Both ovariectomy (OVX) and gastrectomy (GX) cause osteopenia in several animal species including humans. While the effect of OVX has been ascribed to estrogen deficiency, the underlying mechanism behind GX-induced osteopenia is poorly understood. LÄS MER