Sökning: "zoledronic acid"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden zoledronic acid.

  1. 1. Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors

    Författare :Ulrika Bäckman; Rolf Christofferson; Sven Påhlman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Angiogenesis; Neuroblastoma; MYCN; VEGF; SU11657; SU5416; TNP-470; zoledronic acid; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. LÄS MER

  3. 2. Benefits and harms of Bisphosphonates : an observational study

    Författare :Jonathan Bergman; Peter Nordström; Miia Kivipelto; Håkan Melhus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; osteoporosis; fracture; alendronate; risedronate; zoledronic acid; glucocorticoid; mortality; osteonecrosis; register; registry; real-world evidence; epidemiology; Geriatrics; geriatrik; epidemiologi; Epidemiology;

    Sammanfattning : Background: Bisphosphonates are first-line treatment for osteoporosis, but osteoporosis is considered an undertreated disease. The general aim of this dissertation was to further study the benefits and harms of bisphosphonates. LÄS MER

  4. 3. Biomaterials as carriers for bone active molecules-An approach to create off-the-shelf bone substitutes

    Författare :Deepak Raina; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomaterials; Bone tissue engineering; Bone morphogenic protein-2; Zoledronic acid ZA ; calcium sulphate; Hydroxyapatite; Gelatin;

    Sammanfattning : Bone tissue is commonly transplanted during orthopedic surgeries, primarily for the management of bone defects caused by trauma or various orthopedic conditions including, but not limited to, infections and tumours. Bone grafts are a surgeon’s choice, but their associated drawbacks are paving the way for biomaterial based bone graft substitutes. LÄS MER

  5. 4. Medication-related osteonecrosis of the jaw : occurence, risk factors, pathogenesis & treatment

    Författare :Fredrik Hallmer; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The antiresorptive drugs bisphosphonates and denosumab arewidely used to preserve bone strength by inhibiting osteoclast mediatedbone resorption. High dose intravenous bisphosphonatesand high dose denosumab are mainly used to treat skeletal relatedevents in patients with metastatic bone disease such as metastaticbreast cancer and metastatic prostate cancer or in patients withmultiple myeloma. LÄS MER

  7. 5. Effects of antiresorptive agents on inflammation and bone regeneration in different osseous sites - experimental and clinical studies

    Författare :Carina Cardemil; Peter Thomsen; Cecilia Larsson Wexell; Bente Brokstad Herlofson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Qntiresorptive agents; ovariectomised rat; osteoporosis; skeletal site; differences osteonecrosis of the jaw; osseointegration; bone substitute; inflammation; bone regeneration; gene expression; histomorphometry; Micro-CT; antiresorptive agents; ovariectomised rat; osteoporosis; skeletal site differences; osteonecrosis of the jaw; osseointegration; bone substitute; inflammation; bone regeneration; gene expression; histomorphometry; Micro-CT;

    Sammanfattning : The biological mechanisms involved in bone regeneration in osteoporotic bone and the effect of antiresorptive drugs in relation to surgically inserted biomaterials are not fully understood. Improved osseointegration of titanium implants but also adverse effects of antiresorptive therapies, such as osteonecrotic jaw have been described in the literature. LÄS MER