Sökning: "TLRs and CpG"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden TLRs and CpG.

  1. 1. Immunological Checkpoint Blockade and TLR Stimulation for Improved Cancer Therapy

    Författare :Sara Mangsbo; Thomas Tötterman; Angelica Loskog; Rolf Kiessling; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CpG ODNs; TLR-9; CTLA-4; PD-1; PD-L1; B7. H1; immunotherapy; checkpoint blockade; bladder cancer; cancer; complement; TLRs; Compstatin; properdin; C3; experimental animal model; whole blood loop system; combination therapies; Clinical immunology; Klinisk immunologi; Tumour immunology; Tumörimmunologi; immunologi; Immunology;

    Sammanfattning : This thesis concerns the investigation of novel immunotherapies for cancer eradication. CpG therapy was used in order to target antigen-presenting cells (APCs), facilitating antigen presentation and activation of T cells. LÄS MER

  3. 2. Role of Toll-like receptors in airway inflammation

    Författare :Anne Månsson; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphocytes; peripheral blood; allergic rhinitis; tonsils; eosinophils; specific allergen immunotherapy;

    Sammanfattning : Toll-like receptors (TLRs) are germline-encoded pathogen-recognition receptors that detect different microbial structures and activate the immune system. The human TLR family presently comprises ten members (TLR1-TLR10), each with distinct properties. LÄS MER

  4. 3. Therapeutic dendritic cell vaccination against human papillomavirus

    Författare :Merja Nurkkala Karlsson; Göteborgs universitet; []
    Nyckelord :human papillomavirus; therapeutic dendritic cell vaccination; cholera toxin; T cells; TLRs and CpG;

    Sammanfattning : Cervical cancer, which is caused by infection with human papillomavirus (HPV), is the second most common cancer among women worldwide, leading to 230000 deaths annually. The two currently available HPV vaccines can only be used prophylactically, so they are of no use to the 291 million women who are already infected and at risk of developing cancer. LÄS MER

  5. 4. Activation and dysregulation of innate immunity in HIV-1 and HIV-2 infections

    Författare :Salma Nowroozalizadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Toll-like receptors (TLRs) are pattern recognition receptors, expressed by antigen presenting cells (APCs) that recognize conserved molecular patterns of diverse microorganisms. TLR triggering activates APCs, leading to expression of innate effector molecules and signals that initiate adaptive immune responses. LÄS MER

  7. 5. Characterization of host and microbe interactions affecting adherence, clearance and systemic spread of S. pneumoniae

    Författare :Sofia Dahlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Streptococcus pneumoniae (the pneumococcus) mainly gives rise to diseases of the respiratory tract, such as pneumonia, acute otitis media and sinusitis, but it also causes severe invasive diseases, such as meningitis and sepsis. The pneumococcus accounts for approximately two million deaths world-wide every year, the majority of which are children in developing countries. LÄS MER