Sökning: "Bone Development"

Visar resultat 1 - 5 av 519 avhandlingar innehållade orden Bone Development.

  1. 1. Bone density, bone geometry and bone development in young men - the importance of pubertal timing and fracture history

    Författare :Anna Darelid; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peak bone mass; bone mineral density; bone development; fracture; young adulthood; men;

    Sammanfattning : Background and objective: Peak bone mass, the maximal bone mass attained in young adulthood, is an important factor of the lifetime risk of developing osteoporosis. The aim of this thesis was to study the development of bone mineral density (BMD) and bone geometry around the time of peak bone mass in men, and also to investigate the association between pubertal timing, fracture history, bone turnover markers and BMD and bone geometry in young men. LÄS MER

  3. 2. Bone mass in the young athlete

    Författare :Ulrika Pettersson; Ronny Lorentzon; Olle Svensson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone mass; bone area; physical activity; muscle strength; body constitution; amenorrhea; puberty; adolescents; young aduts;

    Sammanfattning : Bone mass and bone size accumulate during childhood and adolescence and peak in the twenties. The obtained peak bone mass has been suggested to be a major determinant of bone mass even in the very elderly. LÄS MER

  4. 3. Multimodal and multiscale characterization of bone and bone interfaces in health and disease

    Författare :Chiara Micheletti; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone; osseointegration; characterization; mineralization; ultrastructure; diabetes; osteoporosis; MRONJ; surface functionalization; local drug delivery; titanium; bioactive glass; imaging; spectroscopy; microscale; nanoscale; micro-computed X-ray tomography; micro-Raman spectroscopy; scanning electron microscopy; transmission electron microscopy; PFIB-SEM tomography; electron tomography;

    Sammanfattning : Seeing is believing. Our understanding of phenomena often involves their direct observation. However, bone architecture is challenging to visualize given its multi-level hierarchical organization. LÄS MER

  5. 4. Development of Novel Models for Studying Osteoclasts

    Författare :Christian Thudium; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoclast; Osteopetrosis; Osteoporosis; Bone; Hematopoiesis; Gene Therapy; Mouse Models; oc oc; RANK KO;

    Sammanfattning : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. LÄS MER

  7. 5. Molecular regulators in cartilage and bone formation

    Författare :Thomas Engstrand; Uppsala universitet; []
    Nyckelord :Medical sciences; cartilage; bone; TGF-beta; BMP; noggin; gene therapy; gene targeting; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Cartilage functions as a scaffold for bone formation during development. This process, endochondral ossification, is regulated by systemic hormones and local growth factors. LÄS MER