Sökning: "NT-4"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet NT-4.

  1. 1. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

    Författare :Peter Wiklund; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NT-4; NT-3; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. LÄS MER

  3. 2. Neurothrophins in the development of the gustatory system and teeth

    Författare :Christopher A Nosrat; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gustation; gustatory; taste buds; neurotrophins; NGF; BDNF; NT-3; NT-4; GDNF; GFRalpha-l; GFRalpha-2; knockout; innervation; development; tooth; tooth development; odontogene sis. Christopher A. Nosrat; 1997;

    Sammanfattning : Flavors of taste are detected by a set of microscopical cellular aggregates called the taste buds, present in different arrangements on the upper surface of the tongue and other areas in the mouth. Taste buds are chemosensors that can detect different taste qualities such as sweet, sour, bitter, salt and umami. LÄS MER

  4. 3. Regulation of neurotrophins and their receptors : molecular aspects and functional implications

    Författare :Tuija Salin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :neurotrophin; nerve growth factor; brain-derived neurotrophic factor; neurotrophin-3; neurotrophin-4; glia; gliosis; neuron; tyrosine kinase receptor; transgenic; null mutation; gene; exon; intron; mRNA;

    Sammanfattning : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. LÄS MER

  5. 4. A Muscle Perspective on the Pathophysiology of Amyotrophic Lateral Sclerosis : Differences between extraocular and limb muscles

    Författare :Vahid M. Harandi; Jingxia Liu; Fatima Pedrosa Domellöf; Per Stål; Fawzi Kadi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuromuscular junctions; Extraocular muscles; Skeletal muscle; Neurotrophic factor; Wnt; Motor neuron disease; Amyotrophic lateral sclerosis; SOD1G93A mice; molekylärbiologi; Molecular Biology;

    Sammanfattning : Background: Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disorder. ALS has been traditionally believed to be primarily a motor neuron disease. LÄS MER

  7. 5. Development requirements of neurotrophins in the mammalian nervous system

    Författare :Wael M Elshamy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The survival of the mammalian peripheral nervous system neurons has long been known to depend on neurotrophic factor support during the period of programmed cell death. In fact this was the original hypothesis, put forward after the discovery of the prototype, nerve growth factor (NGF). LÄS MER