Sökning: "neurotrophin"

Visar resultat 1 - 5 av 61 avhandlingar innehållade ordet neurotrophin.

  1. 1. Effects of Inflammatory Mediators on Pulmonary Airways

    Detta är en avhandling från Medicinska fakulteten, Lunds universitet

    Författare :Ofir Bachar; Lund University.; Lunds universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electric ?eld stimulation; bradykinin; airway; tumor necrosis factor a; Respiratory system; nitric oxide; Andningsorganen; Toll-like receptor; prostaglandin E2; neurotrophin; allergy;

    Sammanfattning : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. LÄS MER

  2. 2. PACAP in adult sensory neurons - implications in injury and pain

    Detta är en avhandling från Helen Jongsma Wallin, Physiological Sciences, BMC F10, 221 84 Lund, Sweden

    Författare :Helen Jongsma Wallin; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve injury; PAC1; PACAP; neurotrophin; neuropeptide; inflammatory pain; inflammation; gracile nuclei; DRG; formalin test; neurofysiologi; neuropsykologi; Neurologi; neurophysiology; neuropsychology; Neurology; trk;

    Sammanfattning : The data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. LÄS MER

  3. 3. PACAP and orphanin FQ/nociceptin -Distribution, importance and regulation in sensory neurons and spinal cord

    Detta är en avhandling från Lina Pettersson, Physiological Sciences, Neuroendocrine Cell Biology, BMC F10, 221 84 Lund, Sweden

    Författare :Lina Pettersson; Lund University.; Lunds universitet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; trk; spinal cord; sensory neuron; rat; PAC1; PACAP; ORL1; OFQ N; neurotrophin; neuropeptide; nerve transection; nerve compression; inflammatory pain; BDNF; DRG;

    Sammanfattning : Neuropeptide expression in the nervous system is abundant and plastic, and an altered expression after injury is an example of a functional response, helping the neuron to cope with adverse changes, and involves effects on differentiation, synthesis, repair/regeneration, survival, and modulation of signal transmission. I have investigated the distribution/expression of the neuropeptides, orphanin FQ/nociceptin (OFQ/N) and pituitary adenylate cyclase activating polypeptide (PACAP), under normal conditions, in response to nerve injuries, and also studied sensory responses in mice deficient for the PAC1 receptor (PAC1-/-). LÄS MER

  4. 4. Brain neurotrophin levels and mouse behavior : relationship to environmental influences

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC)

    Författare :Shun-Wei Zhu; Karolinska Institutet.; Karolinska Institutet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental Enrichment; Intermittent Individual Housing; Physical Exercise; Anxiety; NGF; BDNF; Dorsal Hippocampus; Ventral Hippocampus;

    Sammanfattning : All normal functions over the lifetime of an animal are based on a dynamic balance of at least three fundamental elements: brain, environment and behaviour. This thesis investigated different aspects of these three elements and revealed novel interactions of brain neurotrophins, environmental influences and emotional behaviour in mice. LÄS MER

  5. 5. Role of Endogenous BDNF and NT3 for Synaptic Transmission and Plasticity in the Dentate gyrus

    Detta är en avhandling från Section for Restorative Neurology, BMC A11, SE-221 84 Lund, Sweden

    Författare :Klara Olofsdotter; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; dentate gyrus; GABA; glutamate; synaptic transmission; synaptic plasticity; Brain-derived neurotrophic factor; neurotrophin 3; Neurologi; neurophysiology; neuropsychology; Neurology; electrophysiology; neurofysiologi; neuropsykologi;

    Sammanfattning : The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. LÄS MER