Sökning: "transgenic"

Visar resultat 1 - 5 av 530 avhandlingar innehållade ordet transgenic.

  1. 1. Studies of the function of platelet-derived growth factor and glial fibrillary acidic protein in vivo : a transgenic approach

    Författare :Milos Pekny; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  2. 2. Of mice and men : SOD1 associated human amyotrophic lateral sclerosis and transgenic mouse models

    Författare :Karin Sixtensdotter Graffmo; Thomas Brännström; Stefan Marklund; Elisabeth Englund; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aggregates; ALS; amyotrophic lateral sclerosis; inclusions; misfolded; vacuolisation; SOD1; transgenic; Pathology; Patologi;

    Sammanfattning : Amyotrophic lateral sclerosis, ALS, is a progressive fatal neurodegenerative disorder affecting motor neurones in motor cortex, brain stem and spinal cord. This inevitably leads to paralysis, respiratory failure and death. LÄS MER

  3. 3. Molecular characterization of prostate hyperplasia in prolactin transgenic mice

    Författare :Karin Dillner; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Prolactin-transgenic; mouse; prolactin; prostate hyperplasia; gene expression analysis;

    Sammanfattning : Benign prostatic hyperplasia (BPH) and prostate cancer are age-related diseases, affecting a majority of elderly men in the western world, and are known to be influenced by several different hormones, including sex hormones. Although the hormone prolactin (PRL) is well known to exert trophic effects on prostate cells, its involvement in the pathophysiology is still poorly characterized. LÄS MER

  4. 4. Effects of PGC1a-induced exercise adaptations in muscle on plasticity and recovery mechanisms in the CNS

    Författare :Lars O Karlsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle; brain; exercise; transgenic; PGC-1α; FNDC5; irisin;

    Sammanfattning : In this thesis, we sought to determine if muscle-derived exercise-induced signaling via PGC-1α muscle activation influences neuroplasticity under physiological or pathophysiological conditions. For this purpose, transgenic mice with muscle-specific overexpression of PGC-1α that display an endurance exercise muscle phenotype were evaluated in models of cranial irradiation and photothrombotic stroke, as well as in aging and in a voluntary running paradigm. LÄS MER

  5. 5. Effects of growth hormone on bone tissue in transgenic mice

    Författare :Jonas Sandstedt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; bone; ovariectomy; orchidectomy; growth; Interleukin-6; titanium; transgenic mice;

    Sammanfattning : Growth hormone (GH) affect bone-tissue in both humans and rodents. Also sex steroids are important for growth and the maintenance of normal bone physiology. The specific aims of this study were to investigate how high levels of GH affects bone tissue in mice and to determine whether these effects are dependent on an intact gonadal function. LÄS MER