Sökning: "Neuromuscular junctions"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden Neuromuscular junctions.

  1. 1. Modulation of Neuronal Functions : the Role of SLC10A4

    Författare :Kalicharan Patra; Klas Kullander; Håkan Aldskogius; Per Svenningsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; acetylcholine; central nervous system; neuromuscular junctions; electrophysiology; monoamine; synaptic transmission; neuromodulation; Neuroscience; Neurovetenskap;

    Sammanfattning : Mental health of a person depends on the correct functioning of the brain. The brain and the spinal cord contain many types of cells, of which one important type are called the neurons. Neurons are special in the way they connect to each other to form large networks. LÄS MER

  3. 2. Function and targets of the Urm1/Uba4 conjugation machinery in Drosophila melanogaster

    Författare :Behzad Khoshnood; Caroline Grabbe; Tor Erik Rusten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Urm1; Uba4; MOCS3; Tax; HTLV; Posttranslational modification; ubiquitin-like modifiers; UBL; PTM; JNK; neuromuscular junctions; signaling; molekylärbiologi; Molecular Biology;

    Sammanfattning : Posttranslational modification (PTM) of proteins is essential to maintain homeostasis and viability in all eukaryotic cells. Hence, besides the sequence and 3D folding of a polypeptide, modification by multiple types of PTMs, ranging from small molecular groups to entire protein modules, adds another layer of complexity to protein function and regulation. LÄS MER

  4. 3. A Muscle Perspective on the Pathophysiology of Amyotrophic Lateral Sclerosis : Differences between extraocular and limb muscles

    Författare :Vahid M. Harandi; Jingxia Liu; Fatima Pedrosa Domellöf; Per Stål; Fawzi Kadi; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuromuscular junctions; Extraocular muscles; Skeletal muscle; Neurotrophic factor; Wnt; Motor neuron disease; Amyotrophic lateral sclerosis; SOD1G93A mice; molekylärbiologi; Molecular Biology;

    Sammanfattning : Background: Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disorder. ALS has been traditionally believed to be primarily a motor neuron disease. LÄS MER

  5. 4. Morphologican and functional studies on the Drosophila neuromuscular system during postembryonic stages

    Författare :Ana Beramendi; Rafael Cantera; Prof. Carlos Dotti; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drosophila; neuromuscular system; Rel-proteins; fly brain; rhythmic morphology; aging; ; Neurobiology; Neurobiologi;

    Sammanfattning : The nervous system of the fruit fly Drosophila melanogaster has emerged as an excellent model for fundamental neuroscience as well as for biomedical research of human neurological diseases. In this thesis, two aspects of the neuromuscular system have been investigated: the role of the IkB-protein Cactus in the larval neuromuscular junction and the morphology of motor terminals throughout adult life. LÄS MER

  7. 5. Extraocular Muscles in Amyotrophic Lateral Sclerosis

    Författare :Anton Tjust; Fatima Pedrosa Domellöf; Mona Lindström; Thomas Brännström; Eva Hedlund; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; EOM; Satellite cells; innervation; neuromuscular disease; neurodegenerative disease; anatomi; Human Anatomy;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease of motor neurons characterized by muscle paralysis and death within 3-5 years of onset. However, due to unknown mechanisms, the extraocular muscles (EOMs) remain remarkably unaffected. LÄS MER