Sökning: "NOD mouse"

Visar resultat 6 - 10 av 38 avhandlingar innehållade orden NOD mouse.

  1. 6. Dissecting the role of micro-RNAs in diabetes

    Författare :Caroline Bolmeson; Create Health; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Sammanfattning : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. LÄS MER

  3. 7. Somatostatin Receptor Expression and Biological Functions in Endocrine Pancreatic Cells

    Författare :Eva Ludvigsen; Stellan Sandler; Eva Tiensuu Janson; Mats Stridsberg; Frank Sundler; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; somatostatin; somatostatin receptors; somatostatin analogues; NOD mouse; type 1 diabetes; pancreatic islets; BON-1 cells; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Type 1 diabetes is resulting from the selective destruction of insulin-producing beta-cells within the pancreatic islets. Somatostatin acts as an inhibitor of hormone secretion through specific receptors (sst1-5). LÄS MER

  4. 8. Aspects of T cell development contributing to autoimmunity

    Författare :Maria Carlsén; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FTOC; T cell development; Type 1 diabetes; p53; Insulin; NOD; Negative selection; TGF-β; Tolerance; Thymus; Conditional cre lox knock out; Autoimmunity;

    Sammanfattning : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. LÄS MER

  5. 9. Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes

    Författare :Nádia Duarte; Dan Holmberg; David Serreze; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; type 1 diabetes; NOD mouse; susceptibility loci; Idd6; Lrmp; gene; NKT; CD1d; TCR; mast cells; Immunologi; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. LÄS MER

  7. 10. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

    Författare :Julia Nilsson; Autoimmunitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

    Sammanfattning : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. LÄS MER