Sökning: "pancreatic islets"

Visar resultat 1 - 5 av 204 avhandlingar innehållade orden pancreatic islets.

  1. 1. Leukocytes in Angiogenesis Learning from Transplanted Pancreatic Islets

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Gustaf Christoffersson; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiogenesis; pancreatic islet transplantation; islets of Langerhans; diabetes mellitus; leukocytes; neutrophils; macrophages; pericytes; MMP-9; VEGF-A; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. LÄS MER

  2. 2. CFTR in pancreatic islets

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Anna Edlund; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

    Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER

  3. 3. Microencapsulation of Pancreatic Islets A Non-Vascularised Transplantation Model

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Bohman; Uppsala universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; NATURAL SCIENCES Biology Cell and molecular biology Cell biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Cellbiologi;

    Sammanfattning : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. LÄS MER

  4. 4. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Joey Lau; Uppsala universitet.; [2008]
    Nyckelord :Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

    Sammanfattning : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. LÄS MER

  5. 5. The Microvasculature of Endogenous and Transplanted Pancreatic Islets Blood Perfusion, Oxygenation and Islet Endocrine Function

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Richard Olsson; Uppsala universitet.; [2006]
    Nyckelord :Cell biology; diabetes mellitus; pancreatic islets; islet transplantation; vascular engraftment; islet microcirculation; oxygenation; blood flow; protein biosynthesis; Cellbiologi;

    Sammanfattning : Type 1 diabetes mellitus affects millions of people worldwide. Islet transplantation is a minimal invasive surgical procedure that restores euglycemia and halts the progression of diabetic complications. However, despite transplantation of islets from multiple donors most patients reverse to hyperglycemia within five years. LÄS MER