Sökning: "inflammasome"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet inflammasome.

  1. 1. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections

    Detta är en avhandling från Örebro : Örebro university

    Författare :Berhane Asfaw Idosa; Örebro universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteremia; Cytokines; Gene variants; Inflammasome; Inflammation; Innate immunity; Neutrophils; Meningitis; Neisseria meningitidis; Biomedicin; Biomedicine;

    Sammanfattning : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. LÄS MER

  2. 2. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Deepti Verma; Linköpings universitet.; Linköpings universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik;

    Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER

  3. 3. On causes and regulation of anti-viral defence in asthma and COPD

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Mandy Menzel; Lunds universitet.; Lund University.; [2018]
    Nyckelord :asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; ; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress; asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress;

    Sammanfattning : Rhinovirus infection is a main trigger of asthma and COPD exacerbations. dsRNA, a viral replication intermediate, is sensed by pattern recognition receptors in the airway epithelium leading to down-stream induction of anti-viral interferons. LÄS MER

  4. 4. Regulation of inflammasomes by host- and pathogen-derived factors

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Dora Hancz; Lunds universitet.; Lund University.; [2019]
    Nyckelord :Innate Immunity; pattern recognition receptors; inflammasome; Streptococcus pyogenes;

    Sammanfattning : The term inflammasome was first coined in 2002 and describes an intracellular multiprotein complex mediating inflammation by inducing the release of pro-inflammatory cytokines (IL-1β and IL-18) and a lytic form of cell death called pyroptosis. Since then, an impressive amount of research has revealed many details about the mechanisms of inflammasome activation as well as the functional relevance of inflammasome activation in different contexts. LÄS MER

  5. 5. Innate immunity in human atherosclerosis and myocardial infarction Role of CARD8 and NLRP3

    Detta är en avhandling från Örebro : Örebro University

    Författare :Geena Paramel Varghese; Örebro universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Inflammasome; NLRP3; CARD8; Myocardial infarction; Endothelial cells; Polymorphism; IL-1β; Cytokines; Innate immunity; Biomedicin; Biomedicine;

    Sammanfattning : Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). LÄS MER