Sökning: "susceptibility loci"

Visar resultat 1 - 5 av 126 avhandlingar innehållade orden susceptibility loci.

  1. 1. The genetics of systemic lupus erythematosus : Mapping of susceptibility loci for human SLE

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna-Karin B. Lindqvist; Uppsala universitet.; [1999]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Systemic lupus erythematosus; complex diseases; genetic susceptibility; linkage analysis; genome scan; candidate gene; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting organs such as skin, jointsand kidneys. Characteristic for the disease is increased production of autoantibodies, in particular against dsDNA. Previous studies of SLE in mouse models and in humans indicate polygenic inheritance and genetic heterogeneity. LÄS MER

  2. 2. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Michael Jewett; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. LÄS MER

  3. 3. Genetic studies of stroke in Northern Sweden

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Sofie Nilsson Ardnor; Umeå universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; linkage; genome wide scan; susceptibility loci; association; candidade gene; PDE4D; PIK3R1; extended pedigree; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics Medical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik Medicinsk genetik;

    Sammanfattning : Stroke is a common disorder of later life with a complex etiology, including both environmental and genetic risk factors. The inherited predisposition is challenging to study due to the complexity of the stroke phenotype. LÄS MER

  4. 4. Genetic analysis of murine malaria

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Susana Campino; Umeå universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Malaria; genetic analysis; Plasmodium; wild derived inbred strains; loci; cerebral malaria; hyperparasitaemia.; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; genetik; Genetics;

    Sammanfattning : Malaria, an infectious disease caused by Plasmodium parasites, is one of the major world-scale health problems. Despite the efforts aimed at finding an effective way to control the disease, the success has been thwarted by the emergence of parasite drug resistance and mosquito resistance to insecticides. LÄS MER

  5. 5. Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Nádia Duarte; Umeå universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; type 1 diabetes; NOD mouse; susceptibility loci; Idd6; Lrmp; gene; NKT; CD1d; TCR; mast cells; Immunologi; MEDICINE Microbiology; immunology; infectious diseases Immunology; MEDICIN Mikrobiologi; immunologi; infektionssjukdomar Immunologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. LÄS MER