Sökning: "NOD mouse"

Visar resultat 16 - 20 av 38 avhandlingar innehållade orden NOD mouse.

  1. 16. A sub-phenotype approach to dissect the genetic control of murine type 1 diabetes

    Författare :Marie-Louise Bergman; Leif Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. LÄS MER

  3. 17. Molecular and cellular mechanisms in the development of IDDM in non-obese diabetic mice

    Författare :Cecilia Rietz; Inger Lundkvist; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : Insulin dependent diabetes mellitus (IDDM) is a disease caused by autoimmune destruction of the insulin producing b cells in the pancreas. The leukocytic infiltration into the b cell islets preceding disease is called insulitis. LÄS MER

  4. 18. Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors

    Författare :Neivis Tormo-Badia; Diabetes - immunovirologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. LÄS MER

  5. 19. Diabetes pathogenesis : role of natural killer cells, T cells and a novel neuropeptide

    Författare :Hanna Brauner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes is a major health problem affecting nearly 5% of the population world wide. It is a heterogeneous group of diseases with the autoimmune type 1 diabetes (T1D) and the metabolic type 2 diabetes (T2D) being the major types. LÄS MER

  7. 20. T cells, Cytokines, and Genetic Factors in Autoimmunity Studies of experimental models of arthritis and sialadenitis

    Författare :Åsa Johansson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Collagen-induced arthritis Sialadenitis Mice Knockout Linkage analysis T cells Cytokines; muscle system; Skeleton; reumatologi; muskelsystem; Skelett;

    Sammanfattning : To understand the pathogenesis of autoimmune diseases we have to consider the problem from different angles. Animal models provide a tool to further understand these complex diseases, as the influence of genetic and environmental factors could be limited. LÄS MER