Sökning: "type 1 diabetes"

Visar resultat 1 - 5 av 897 avhandlingar innehållade orden type 1 diabetes.

  1. 1. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Detta är en avhandling från Units of Epigenetics and Diabetes and Molecular Metabolism, Department of Clinical Sciences, Malmö

    Författare :Siri Malmgren; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER

  2. 2. Fat metabolism in type 1 diabetes

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :SIMON REGNÉLL; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 1 diabetes;

    Sammanfattning : .... LÄS MER

  3. 3. The genetic background of gestational diabetes mellitus

    Detta är en avhandling från Dept of Diabetes and Celiac Disease

    Författare :Anastasia Papadopoulou; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gestational diabetes mellitus; HLA; TCF7L2; PTPN22; Post partum diabetes; Type 1 Diabetes; Type 2 Diabetes; Islet Cell Autoantibodies;

    Sammanfattning : The aims of this work is to better determine the genetic background of gestational diabetes (GDM) and to examine how specific genes affect the development of diabetes post partum. In the DiPiS (Diabetes Prediction in Skåne) study we typed for HLA-DQB1 alleled, the transcription factor 7-like 2(TCF7L2) rs7903146, rs12255372 and rs7901695 SNPs, the 1858 C>T SNP of the protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and we tested for the presence of islet cell autoantibodies against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. LÄS MER

  4. 4. The Perfect Storm? Gluten and type 1 diabetes

    Detta är en avhandling från Dept of Diabetes and Celiac Disease

    Författare :Emma Adlercreutz; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NKG2D; Celiac disease autoimmunity; Gluten; Type 1 diabetes; Perinatal risk;

    Sammanfattning : Aim: The general objective of the present research was to study the association between type 1 diabetes and celiac disease, and the effects of dietary gluten on the risk of developing type 1 diabetes. More specific aims were as follows: to estimate the prevalence of celiac-disease-associated autoantibodies in children with type 1 diabetes; to study the connection between non-HLA genetic risk markers and autoantibodies associated with type 1 diabetes and celiac disease during the first year after diagnosis of type 1 diabetes; to investigate the effect of gluten on the risk of developing type 1 diabetes; to evaluate the impact of perinatal factors on the risk of developing both type 1 diabetes and celiac disease. LÄS MER

  5. 5. FOXC2 and CAPN10 as candidate genes for obesity, insulin resistance and type 2 diabetes

    Detta är en avhandling från Endocrinology

    Författare :Emma A Nilsson; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; Type 2 diabetes; Genetics; Obesity;

    Sammanfattning : The worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. LÄS MER