Sökning: "Lund Institutionen för kliniska vetenskaper"

Visar resultat 16 - 20 av 85 avhandlingar innehållade orden Lund Institutionen för kliniska vetenskaper.

  1. 16. Mechanisms of Ischemic Brain Injury- studies in murine hippocampal slice cultures

    Författare :Anna Rytter; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neuropsychology; Neurology; adenosine; caspases; hypothermia; in vitro; hippocampus; ischemia; neurofysiologi;

    Sammanfattning : Cerebral ischemia is a major cause of mortality and morbidity in the western world. Even though much effort has been put into research and development of effective drugs against ischemic damage there is to date no effective pharmacological brain protective treatment. LÄS MER

  3. 17. Vascular actions of antimicrobial peptides

    Författare :Cristina Ciornei; Sektion II; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; vascular smooth muscle; sepsis; nitric oxide; human antimicrobial peptide LL-37; Antimicrobial peptides; lipopolysaccharide; bactericidal permeability-increasing protein;

    Sammanfattning : The present thesis focuses on the vascular effects of antimicrobial peptides especially mechanisms involving the vasodilator nitric oxide (NO), which is released from the blood vessel wall during inflammatory conditions such as sepsis. Bacterial lipopolysaccharide stimulates the expression of nitric oxide synthase (iNOS), which increases the NO production in vascular tissues or cultured vascular smooth muscle cells (VSMC). LÄS MER

  4. 18. Battling Bacterial Biofilm - antibiotic regimens targeting Grampositive pathogens in biofilm

    Författare :Anna Holmberg; Sektion III; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biofilm; antibiotic susceptibility; prosthetic joint infection; MBEC; Enterococcus faecalis; Enterococcus faecium; Propionibacterium acnes.;

    Sammanfattning : AbstractBacteria in most environments encase themselves in a hydrated matrix of polysaccharide and protein, forming organized communities called biofilms. In the biofilm bacteria are protected against hostile environments. Biofilms are important clinically because of their persistence despite host defence and their recalcitrance to antimicrobials. LÄS MER

  5. 19. Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target

    Författare :Magnus Hansson; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; Bioenergetik; Bioenergetics; neuropsykologi; toxikologi; neurofysiologi; Neurologi; Neurology; neurophysiology; neuropsychology; Neurodegeneration; Mitochondria; Brain; Pharmacological sciences; pharmacognosy; pharmacy; Farmakologi; toxicology;

    Sammanfattning : There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. LÄS MER

  7. 20. HIV-2 infection in Guinea-Bissau, West Africa, with special reference to clinical, immunological and epidemiological aspects

    Författare :Hans Norrgren; Sektion III; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infections; Africa; Guinea-Bissau; AIDS; HIV-1; HIV-2; Infektioner;

    Sammanfattning : We have followed a cohort of police officers in Guinea-Bissau between 1990 and 1997 for the study of clinical, immunological and epidemiological aspects of HIV-2 infection. Initially the prevalence of HIV-2 was high (11.6 %) and HIV-1 infection was rare (0. LÄS MER