Sökning: "DNA replication"

Visar resultat 41 - 45 av 307 avhandlingar innehållade orden DNA replication.

  1. 41. The Smc5/6 complex : linking DNA replication with chromosome segregation

    Författare :Kristian Jeppsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In order to faithfully propagate the genetic material from one generation to the next, cells need to properly replicate and segregate their chromosomes. The three well-conserved eukaryotic Structural Maintenance of Chromosomes (SMC) protein complexes, cohesin, condensin and the Smc5/6 complex (Smc5/6) organize chromosomes to ensure that the daughter cells receive a full complement of chromosomes. LÄS MER

  3. 42. Exploring the Cell Cycle of Archaea

    Författare :Magnus Lundgren; Rolf Bernander; William Margolin; Uppsala universitet; []
    Nyckelord :Microbiology; Archaea; Cell cycle; Replication; Mitosis; Cell division; Mikrobiologi;

    Sammanfattning : Archaea is the third domain of life, discovered only thirty years ago. In a microscope archaea appear indistinguishable from bacteria, but they have been shown to be more closely related to eukaryotes than to bacteria. Especially central information processing is homologous to that of eukaryotes. LÄS MER

  4. 43. Pathology of dNTP dysregulation

    Författare :Phong Tran; Andrei Chabes; Erik Johansson; Ola Hammarsten; Umeå universitet; []
    Nyckelord :dNTP metabolism; DNA replication; mutation rate; cancer; heart development; RNR; SAMHD1; Rrm1; Samhd1; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Deoxyribonucleoside triphosphates (dNTPs) are precursors for DNA replication and repair. Mammalian cells have two distinct biosynthesis pathways to supply dNTPs: de novo and salvage pathways. LÄS MER

  5. 44. Stress response regulation and protein aggregate inheritance in Caulobacter crescentus

    Författare :Frederic Dominique Schramm; Kristina Jonas; Franz Narberhaus; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; stress; protein aggregation; cellular aging; molecular chaperones; heat shock response; DnaK; sigma factor; suppressor genes; DNA replication; starvation; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Many stress conditions a cell encounters threaten the continuation of basic biological processes ultimately endangering its survival. Heat shock and antibiotic exposure can lead to a sudden surge of protein un- and misfolding, while nutrient starvation directly causes a lack of energy and molecular building blocks. LÄS MER

  7. 45. Genomic and transcriptomic sequencing in chronic lymphocytic leukemia

    Författare :Diego Cortese; Richard Professor; Carlos López Otín; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic; lymphocytic; leukemia; CLL; genomics; transcriptomics; DNA; RNA; mutations; NGS; whole-exome; sequencing; prognostic; markers; TP53; SF3B1; RPS15; relapse; stereotyped; subsets.;

    Sammanfattning : Identification of recurrent mutations through next-generation sequencing (NGS) has given us a deeper understanding of the molecular mechanisms involved in chronic lymphocytic leukemia (CLL) development and progression and provided novel means for risk assessment in this clinically heterogeneous disease. In paper I, we screened a population-based cohort of CLL patients (n=364) for TP53, NOTCH1, SF3B1, BIRC3 and MYD88 mutations using Sanger sequencing, and confirmed the negative prognostic impact of TP53, SF3B1 or NOTCH1 aberrations, though at lower frequencies compared to previous studies. LÄS MER