Sökning: "dNTP metabolism"

Hittade 4 avhandlingar innehållade orden dNTP metabolism.

  1. 1. Pathology of dNTP dysregulation

    Författare :Phong Tran; Andrei Chabes; Erik Johansson; Ola Hammarsten; Umeå universitet; []
    Nyckelord :dNTP metabolism; DNA replication; mutation rate; cancer; heart development; RNR; SAMHD1; Rrm1; Samhd1; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Deoxyribonucleoside triphosphates (dNTPs) are precursors for DNA replication and repair. Mammalian cells have two distinct biosynthesis pathways to supply dNTPs: de novo and salvage pathways. LÄS MER

  3. 2. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

    Författare :Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

    Sammanfattning : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. LÄS MER

  4. 3. Regulation of the Expression of Mouse Ribonucleotide Reductase Small Subunit at the Levels of Transcription and Protein Degradation

    Författare :Anna Lena Chabes; Lars Thelander; Ylva Engström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; ribonucleotide reductase; transcription; protein degradation; cell cycle; Molekylärbiologi; Molecular biology; Molekylärbiologi; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Deoxyribonucleic acid (DNA) carries all the genetic information of a cell. Ribonucleotide reductase (RNR) provides balanced pools of all four dNTPs, the building blocks of DNA. These building blocks are needed during DNA synthesis and repair. LÄS MER

  5. 4. Mitochondrial dysfunction and treatment strategies

    Författare :Shuba Krishnan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The mitochondria are essential for cellular energy production and are involved in many processes in the cells. The mitochondria contain their own DNA (mtDNA) that is vital for oxidative phosphorylation since it encodes enzymes of the respiratory chain. LÄS MER