Sökning: "DNA replication"

Visar resultat 1 - 5 av 264 avhandlingar innehållade orden DNA replication.

  1. 1. Replication Dynamics in the DNA Damage Response

    Detta är en avhandling från Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University

    Författare :Petra Groth; Stockholms universitet.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA replication; homologous recombination; DNA double strand-breaks; ionizing radiation; alkylating agents; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES Biology Cell and molecular biology Genetics; NATURVETENSKAP Biologi Cell- och molekylärbiologi Genetik; Molecular Genetics; molekylärgenetik;

    Sammanfattning : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. LÄS MER

  2. 2. Initiation of Mammalian Mitochondrial DNA Replication

    Detta är en avhandling från Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University

    Författare :Elisabeth Jemt; Göteborgs universitet.; Gothenburg University.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication;

    Sammanfattning : Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and they contain their own genome. The mitochondrial DNA (mtDNA) is a double stranded circular molecule that codes for proteins required for cellular respiration and RNA molecules involved in translation of these proteins. LÄS MER

  3. 3. Role of yeast DNA polymerase epsilon during DNA replication

    Detta är en avhandling från Umeå : Medicinsk kemi och biofysik

    Författare :Isabelle Isoz; Umeå universitet.; [2008]
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; DNA polymerase epsilon; eukaryotic DNA replication; fidelity; leading strand; Dpb2; VETERINARY MEDICINE Biochemistry and clinical chemistry; VETERINÄRMEDICIN Biokemi och klinisk kemi;

    Sammanfattning : Each cell division, the nuclear DNA must be replicated efficiently and with high accuracy to avoid mutations which can have an effect on cell function. There are three replicative DNA polymerases essential for the synthesis of DNA during replication in eukaryotic cells. LÄS MER

  4. 4. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

    Detta är en avhandling från Umeå : Medicinsk kemi och biofysik

    Författare :Nasim Sabouri; Umeå universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Sammanfattning : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. LÄS MER

  5. 5. Hepatitis B virus replication and integration

    Detta är en avhandling från Umeå : Medicinsk kemi och biofysik

    Författare :Simon B. Larsson; Göteborgs universitet.; Gothenburg University.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; replication; integration; HBV DNA; HBsAg;

    Sammanfattning : Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no liver disease and express the e antigen (HBeAg). LÄS MER