Sökning: "CLL"

Visar resultat 1 - 5 av 93 avhandlingar innehållade ordet CLL.

  1. 1. Antigen interaction with B cells in two proliferative disorders CLL and MGUS

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Eva Hellqvist; Anders Rosén; Jan Ernerudh; Anne Mette Buhl; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : The aim of the work presented in this thesis was to elucidate B cell interaction with antigen in the two B cell proliferative disorders chronic lymphocytic leukemia (CLL) and monoclonal gammopathy of undetermined significance (MGUS). In the first part we investigated the antigen specificity of CLL cells and characterized Epstein-Barr virus (EBV)-transformed CLL cell lines with regard to phenotype and genotype. LÄS MER

  2. 2. Prognostic markers and DNA methylation profiling in lymphoid malignancies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sujata Bhoi; Richard Rosenquist Brandell; H Denis Alexander; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; CLL; MCL; prognostic markers; micro-RNA; methylation; stereotyped subsets;

    Sammanfattning : In recent years, great progress has been achieved towards identifying novel biomarkers in lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL), at the genomic, transcriptomic and epigenomic level for accurate risk-stratification and prediction of treatment response. In paper I, we validated the prognostic relevance of a recently proposed RNA-based marker in CLL, UGT2B17, and analyzed its expression levels in 253 early-stage patients. LÄS MER

  3. 3. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Detta är en avhandling från Göteborgs universitet

    Författare :Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet.; Gothenburg University.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER

  4. 4. Reappraising prognosis in chronic lymphocytic leukemia

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Panagiotis Baliakas; Richard Brandell Rosenquist; Clemens Wendtner; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; prognosis; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) exhibits remarkable clinical heterogeneity likely reflecting the underlying biological heterogeneity. The genetic landscape of CLL has been recently enriched with mutations within a number of genes proposed as novel prognostic markers. LÄS MER

  5. 5. Recurrent Genetic Mutations in Lymphoid Malignancies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Emma Young; Richard Rosenquist; Larry Mansouri; Lesley Ann Sutton; Dimitar Efremov; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphoid malignancies; mutations; CLL; stereotypy; subsets; PMBL; NFKBIE; EGR2; whole-genome sequencing; Molekylär genetik; Molecular Genetics; Oncology; Onkologi;

    Sammanfattning : In recent years, the genetic landscape of B-cell derived lymphoid malignancies, including chronic lymphocytic leukemia (CLL), has been rapidly unraveled, identifying recurrent genetic mutations with potential clinical impact. Interestingly, ~30% of all CLL patients can be assigned to more homogeneous subsets based on the expression of a similar or “stereotyped” B-cell receptor (BcR). LÄS MER