Sökning: "vascular release"

Visar resultat 1 - 5 av 138 avhandlingar innehållade orden vascular release.

  1. 1. Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha

    Författare :Jenny Öhman; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular; hyperglycemia; osteopontin; NFAT; diabetes; retinopathy; TNF; UTP;

    Sammanfattning : Vascular complications of diabetes account for the majority of morbidity and mortality among diabetic patients. Large clinical trials have identified hyperglycemia as a risk factor in the development of diabetic vascular complications. LÄS MER

  3. 2. Implantation-Site Dependent Differences in Engraftment and Function of Transplanted Pancreatic Islets

    Författare :Joey Lau; Per-Ola Carlsson; Leif Jansson; Carina Carlsson; Caroline Kampf; Annika Tibell; Uppsala universitet; []
    Nyckelord :Cell biology; Type 1 diabetes; pancreatic islets; human islets; islet transplantation; vascular engraftment; revascularization; implantation-site; microenvironment; vascular density; insulin release; pro insulin biosynthesis; glucose oxidation; Cellbiologi;

    Sammanfattning : Transplanting pancreatic islets into the liver through the portal vein is currently the most common procedure in clinical islet transplantations for treating patients with brittle type 1 diabetes. However, most islet grafts fail within a 5-year period necessitating retransplantation. LÄS MER

  4. 3. Vascular Effects of P2 Receptors. Changes in Congestive Heart Failure

    Författare :Malin Malmsjö; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; congestive heart failure; pyrimidine; purine; P2 receptor; vasodilatation; vasoconstriction; hyperpolarisation; EDHF; NO; Vascular; endothelium; Cardiovascular system; Kardiovaskulära systemet;

    Sammanfattning : Extracellular nucleotides induce dilatation and constriction of blood vessels by activation of P2 receptors. In this thesis the vasomotor effects of P2 receptor activation were studied in the rat mesenteric artery, and their changes in congestive heart failure (CHF) were evaluated using in vitro pharmacology, electrophysiology and competitive RT-PCR. LÄS MER

  5. 4. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

    Författare :Anna Zetterqvist; Diabetiska komplikationer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

    Sammanfattning : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. LÄS MER

  7. 5. Role of NFAT (nuclear factor of activated T cells) in vascular smooth muscle

    Författare :Lisa Berglund; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vascular smooth muscle; proliferation; A-285222; osteopontin; AIF-1; diabetes; vascular disease; calcium; glucose; NFAT;

    Sammanfattning : The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. LÄS MER