Sökning: "microenvironment"

Visar resultat 1 - 5 av 238 avhandlingar innehållade ordet microenvironment.

  1. 1. Imaging the tumor microenvironment the dynamics and modification of hypoxia

    Detta är en avhandling från Umeå : Strålningsvetenskaper

    Författare :Anna Ljungkvist; Umeå universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; tumor microenvironment; double hypoxic marker method; proliferation; hypoxia; hypoxic half-life; Radiologisk forskning; MEDICINE Physiology and pharmacology Radiological research; MEDICIN Fysiologi och farmakologi Radiologisk forskning; diagnostisk radiologi; Diagnostic Radiology;

    Sammanfattning : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. LÄS MER

  2. 2. Targeting the prostate tumor microenvironment and vasculature the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

    Detta är en avhandling från Umeå : Medicinsk biovetenskap

    Författare :Sofia Halin; Umeå universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; MEDICINE Morphology; cell biology; pathology Pathology; MEDICIN Morfologi; cellbiologi; patologi Patologi; patologi; Pathology;

    Sammanfattning : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. LÄS MER

  3. 3. Adaptive mechanisms in the hypoxic tumor microenvironment. Functional role of proteoglycans and identification of potential treatment targets

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Julien Menard; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hypoxia; Acidosis; Proteoglycans; Endocytosis; Glioblastoma; Lipid; Caveolin-1; Antibody-drug conjugate;

    Sammanfattning : Cancer cells reside in a complex microenvironment comprising stromal cells and immune cells embedded in an extracellular matrix (ECM). Early on in tumor progression, cells reach a critical volume beyond which blood supply is impaired, leading to a decrease in oxygen levels (hypoxia) and nutrient supply. LÄS MER

  4. 4. Studies of the tumor microenvironment Local and systemic effects exerted by the cross-talk between tumor and stroma cells in pancreatic cancer

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Vegard Tjomsland; Linköpings universitet.; Linköpings universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pancreatic cancer; cancer associated fibroblasts; dendritic cells; IL-1alpha; tumor microenvironment; inflammation; bukspottkörtelcancer; Bukspyttkjertel kreft; MEDICINE; MEDICIN;

    Sammanfattning : Pancreatic cancer is one of the most lethal cancers and despite all research efforts the last 50 years, there are still no effective therapy for this terrible disease. Until quite recently most research in the field of pancreatic duct adenocarcinoma (PDAC) was focused on the tumor cells and mechanisms essential for their proliferation and survival. LÄS MER

  5. 5. Growth factor signaling in the breast tumor microenvironment

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Matteo Bocci; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018]
    Nyckelord :Breast cancer; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; PDGF-C; ALK1;

    Sammanfattning : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. LÄS MER