Sökning: "TNF"

Visar resultat 1 - 5 av 600 avhandlingar innehållade ordet TNF.

  1. 1. TNF-α and neurotrophins in Achilles tendinosis

    Författare :Johan Bagge; Sture Forsgren; Tomas Movin; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Achilles tendon; tendinosis; tendinopathy; neurotrophins; TNF-alpha; physical acitivity; apoptosis; proliferation; pain; remodelling; anatomi; Human Anatomy;

    Sammanfattning : Tenocytes are the principal cells of the human Achilles tendon. In tendinosis, changes in the metabolism and morphology of these cells occur. Neurotrophins are growth factors essential for the development of the nervous system. LÄS MER

  2. 2. TNFalpha expression in monocytes/macrophages

    Författare :Karolina Andersson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; Protein kinase; Macrophage; TNF;

    Sammanfattning : The recognition of microbes or microbial products by leukocytes is a key event in innate immunity. Binding of microbial products to cell surface receptors on phagocytes induce a response that includes the production of inflammatory mediators. One such mediator is the cytokine tumour necrosis factor alpha (TNF). LÄS MER

  3. 3. Signal transduction in macrophages. Intracellular pathways activated by microbial constituents

    Författare :Sandra Olsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; TNF; TLR; dectin-1; lipid rafts; Src; Btk; Macrophages; arachidonate;

    Sammanfattning : Macrophages play an essential role in the defense against infection by phagocytosis and by production of inflammatory mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. LÄS MER

  4. 4. Cytokines in Staphylococcus aureus arthritis. For better for worse

    Författare :Olof H. Hultgren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Staphylococcus aureus; septic arthritis; sepsis; cytokines; IL-4; IL-12; TNF; LTa; IFN-g.;

    Sammanfattning : Septic arthritis is an inflammatory condition in joints caused by in situ residing bacteria accompanied by a septic reaction. Bacteria reach their target via the blood stream and the major human pathogen is Staphylococcus aureus. LÄS MER

  5. 5. p38 MAPK Signalling in Endothelial Apoptosis

    Författare :Simone Grethe; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

    Sammanfattning : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. LÄS MER