Sökning: "tumor progression"
Visar resultat 16 - 20 av 490 avhandlingar innehållade orden tumor progression.
16. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization
Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER
17. The Neuroblastoma Genome and Epigenome - Patient Stratification and Identification of Candidate Genes
Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system, and the most common extracranial tumor of childhood. The prognosis for high-stage NBs is still poor, with survival rates of about 35%. Side-effects of treatment in these young children can also be severe. LÄS MER
18. From 1p3 to PI3K - Studies of neuroblastoma
Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. LÄS MER
19. Regulation of hyaluronan biosynthesis : Expression in vitro and importance for tumor progression
Sammanfattning : Hyaluronan, a component of the extracellular matrix, is synthesized by either of three hyaluronan-synthesizing enzymes termed Has1, Has2 and Has3. The expression level of each Has gene varies between cell types of mesenchymal origin and is differentially regulated in response to external stimuli. LÄS MER
20. Tumor Selective Antiproliferative Naphthoxylosides
Sammanfattning : Proteoglycans (PG) are highly anionic macromolecules consisting of a core protein covalently substituted with long unbranched polysaccharide chains called glycosaminoglycans (GAGs). PGs are central components in multicellular organisms, and they may occur in the extracellular matrix (ECM), at the cell surface, or in the secretory pathway. LÄS MER