Sökning: "tumor progression"

Visar resultat 11 - 15 av 490 avhandlingar innehållade orden tumor progression.

1. 11. Computational Modeling of Cancer Progression

   Författare :Hossein Shahrabi Farahani; Jens Lagergren; Niko Beerenwinkel; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer progression; Bayesian networks; microRNA editing; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

   Sammanfattning : Cancer is a multi-stage process resulting from accumulation of genetic mutations. Data obtained from assaying a tumor only contains the set of mutations in the tumor and lacks information about their temporal order. Learning the chronological order of the genetic mutations is an important step towards understanding the disease. LÄS MER

3. 12. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Författare :Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Sammanfattning : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. LÄS MER

4. 13. Monitoring of neuroendocrine tumor patients undergoing systemic therapies

   Författare :Olof Pettersson; Anders Sundin; Håkan Geijer; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Therapy monitoring; NET; neuroendocrine tumor; computed tomography; CT; PRRT; 177Lu-DOTATATE; TGR; tumor growth rate; theranostics; DOTATOC-PET CT; Radiology; Radiologi; Endokrinologi och Diabetologi; Endocrinology and Diabetology; Oncology; Onkologi;

   Sammanfattning : Monitoring of neuroendocrine tumor (NET) patients undergoing systemic therapies is troublesome as biomarkers capable of detecting tumor responses have been difficult to establish. Changes in the sum of target lesion diameters are used to evaluate the effects of therapy according to the response evaluation criteria in solid tumors (RECIST 1.1). LÄS MER

5. 14. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth

   Författare :Daniel Öhlund; Malin Sund; Peter Naredi; Matthias Löhr; Umeå universitet; []
   Nyckelord :Pancreatic cancer; tumor marker; basement membrane; type IV collagen; type XVIII collagen; matrix metalloproteinase; integrin; autocrine loop; tumor stroma; kirurgi; Surgery;

   Sammanfattning : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. LÄS MER

7. 15. Tumor acidosis in malignant progression and therapy

   Författare :Paola Pellegrini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cancer still represents one of the leading causes of death despite the advances achieved during the past years. Improving the outcome of cancer patients requires the identification of more affective therapeutic strategies and a better understanding of the molecular mechanisms involved in the progression of the disease. LÄS MER