Sökning: "premalignant"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet premalignant.

  1. 1. From 1p3 to PI3K - Studies of neuroblastoma

    Författare :Susanne Fransson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; PI3K; PIK3CD; 1p36; alternative splicing; tumor; neural crest; mucosa; premalignant; tumor suppressor gene; oncogene; gene expression; epigenetics; splicing; signaling; akt; western blot; TaqMan; PIK3R1; p110H; p37H; p85; RAS;

    Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. LÄS MER

  3. 2. Cell cycle regulatory proteins and miRNAs in premalignant lesions and breast cancer

    Författare :Sofie Björner; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. LÄS MER

  4. 3. Mitotic failure and genome stability in benign, premalignant and malignant human tissues

    Författare :Rüdiger G Steinbeck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aneuploidy; CDF; clonal selection; DNA content; image microphotometry; interphase; microsection; nondisjunction; unbalanced telophase;

    Sammanfattning : Mitotic failure may occur throughout the human lifespan. Individual nuclear mistakes will escape detection within the mass of somatic cells. The probability of nondetection increases with progression in development. LÄS MER

  5. 4. The battleground of two Infections and a cancer: Human Papilloma Virus, premalignant lesions of the cervix and their interaction with Human Immunodeficiency Virus in southwestern Nigeria

    Författare :Oliver Ezechi; Socialmedicin och global hälsa; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antiretroviral drugs; Human papilloma virus; cervical cancer; HIV AIDS; pre-cancerous lesions; Nigeria;

    Sammanfattning : Background: The highest numbers of HIV-infected women are in sub- Saharan Africa, where the natural progression of HIV disease in the absence of treatment results in death before the onset of invasive cervical cancer. With improved access to treatment, several studies outside West Africa demonstrated an increased risk of pre-invasive cervical lesions among HIV-infected women and the positive impact of treatment on the outcome. LÄS MER

  7. 5. p53 and neoplastic progression in Barrett's esophagus

    Författare :Stig Ramel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Barrett s esophagus; neoplastic progression; flow cytometry; p53 gene; p53protein; 17p allelic loss; p53 mutations; S phase fractions; aneuploidy; SV 40 large T antigen; elastase-SV 40 T antigen transgenic mice.;

    Sammanfattning : Barrett's esophagus is a condition in which the normal squamous epithelium is replaced by columnar epithelium as a response to acid reflux. It develops as a complication in 10-20% of patients with gastroesophageal reflux disease. LÄS MER