Sökning: "HIF-2alpha"

Hittade 3 avhandlingar innehållade ordet HIF-2alpha.

  1. 1. Hypoxia-Inducible Factors in Tumor Cell Differentiation and Tumor Vascularization

    Detta är en avhandling från Lund University

    Författare :Alexander Pietras; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-2alpha; cancer; notch; angiogenesis; tumor-initiating cells; hypoxia; neuroblastoma; differentiation;

    Sammanfattning : Mammalian cells, including tumor cells, adapt to hypoxia via stabilization of two transcription factors - Hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha. Among other consequences, hypoxia is a main driving force behind angiogenesis. LÄS MER

  2. 2. IGF, PI3K and HIF-2 in Normal and Tumor Development

    Detta är en avhandling från Molecular Medicine

    Författare :Sofie Mohlin; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Hypoxia; Insulin-like Growth Factor; PI3K; HIF-2alpha; Cancer; Development;

    Sammanfattning : Cells adapt to oxygen shortage, hypoxia, by inducing a transcriptional shift governed mainly by Hypoxia Inducible Factor (HIF)-1 and HIF-2. In various cancer forms, including neuroblastoma, high expression of HIF-2α correlates with disseminated disease and poor outcome. LÄS MER

  3. 3. Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells

    Detta är en avhandling från Lund University Department of Laboratory Medicine Division of Molecular Medicine

    Författare :Tobias Löfstedt; Lund University.; Lunds universitet.; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Biomedicinska vetenskaper; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; Biomedical sciences; MXI1; ID2; differentiation; HIF; hypoxia; transcription; cancer; neuroblastoma; Cytologi; onkologi;

    Sammanfattning : Cancer is a major cause of human morbidity and mortality, and the risk of developing cancer is about one in three life times. Neuroblastoma is the most common extra-cranial solid tumor among children and arises from early sympathetic nervous system (SNS) cells arrested in their development. LÄS MER