Sökning: "hypoxia"

Visar resultat 1 - 5 av 432 avhandlingar innehållade ordet hypoxia.

1. 1. Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium

   Författare :Karolina Helczynska; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Differentiation; Hypoxia; Breast cancer; Breast; HiF-1; HiF-2; 3D-cultures; prognosis;

   Sammanfattning : Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. LÄS MER

3. 2. Imaging the tumor microenvironment : the dynamics and modification of hypoxia

   Författare :Anna Ljungkvist; Peggy L. Olive; Umeå universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; tumor microenvironment; double hypoxic marker method; proliferation; hypoxia; hypoxic half-life; Radiologisk forskning; Radiological research; Radiologisk forskning; diagnostisk radiologi; Diagnostic Radiology;

   Sammanfattning : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. LÄS MER

4. 3. Pericytes in Hypoxia and Ischemic Stroke

   Författare :Andreas Enström; Translationell Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pericytes; Ischemic stroke; Hypoxia; Secretome; Transcriptome; RGS5;

   Sammanfattning : Molecular oxygen is essential for most living species. Consequently, hypoxic or ischemic conditions are major cellular stressors and prominent pathological features in ischemic stroke. Stroke is a global health problem and remains the second leading cause of death or disability worldwide. LÄS MER

5. 4. MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS

   Författare :Paulina Kucharzewska; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hypoxia; hypoxia-inducible factor; angiogenesis; anti-angiogenic therapy; endothelial cell; polyamines; microRNA; extracellular membrane vesicles; exosomes; glioblastoma;

   Sammanfattning : Hypoxia, or deficient oxygen levels, is an inherent feature of rapidly expanding tumor tissue. In order to survive in the hostile, hypoxic environment and to restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. LÄS MER

7. 5. Hypoxia, PDGF and VEGF in Vascular Development

   Författare :Ingrid Nilsson; Lena Claesson-Welsh; Randall Johnson; Uppsala universitet; []
   Nyckelord :Cell biology; hypoxia; VEGF; VEGFR-3; PDGF; endothelial cell; embryonic stem cell; angiogenesis; lymphangiogenesis; Cellbiologi;

   Sammanfattning : The mechanisms behind many important aspects of blood- and lymphatic vessel formation have yet not been elucidated in detail. The primary objectives of this thesis have therefore been to study the effects of hypoxia, platelet-derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs) on vascular development and function. LÄS MER