Sökning: "superantigen"

Visar resultat 6 - 10 av 34 avhandlingar innehållade ordet superantigen.

  1. 6. The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice

    Författare :Vinícius Motta; Dan Holmberg; Linda Wicker; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; NOD mouse; CTLA-4; superantigen; T cells; Idd; marginal zone B cells; embryo aggregation chimera; negative selection; Immunogenetics; Immungenetik;

    Sammanfattning : The nonobese diabetic mouse (NOD) is an excellent animal model to study type 1 diabetes. As with some humans, disease in the NOD mouse is effected by a combination of genetic and environmental factors. At least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified so far, both in humans and in the NOD mouse. LÄS MER

  3. 7. Host-bacterium relationship in staphylococcal skin infection

    Författare :Lena Mölne; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Staphylococcus aureus; skin; mice; superantigen; TSST-1; neutrophils; gamma delta T cells; bacterial DNA; CpG ODN;

    Sammanfattning : Skin infections caused by Staphylococcus aureus are commonly occuring, both in the community and in hospitals. Despite the high prevalence of this condition, little is known about the host immune responsiveness and bacterial virulence factors during S. aureus skin infection. LÄS MER

  4. 8. Structural studies of metal-binding proteins revealing dynamic behaviour

    Författare :Maria Håkansson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry; Molekylär biofysik; Molecular biophysics; zinc; magnesium; superantigen; calbindin D9k; X-ray crystallography; staphylococcal enterotoxin; structure; Chemical technology and engineering; Kemiteknik och kemisk teknologi;

    Sammanfattning : The Mg2+ and Mn2+ structures of calbindin D9k have been determined and they reveal a conformational change compared to the structures of apo and (Ca2+)2-calbindin D9k. These findings are unique, since normally calcium and not magnesium is known to induce conformational changes of EF-hand proteins. LÄS MER

  5. 9. T cell Tolerance - Cellular and molecular features of immune regulation

    Författare :Susanna Grundström; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; JAK STAT.; NFkB; suppression; IL-2; superantigen; T cells; tolerance;

    Sammanfattning : The immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. LÄS MER

  7. 10. Staphylococcus aureus in the infantile bowel flora

    Författare :Erika Lindberg; Göteborgs universitet; []
    Nyckelord :Staphylococcus aureus; intestinal; microflora; superantigen; RAPD; bacteria; infants;

    Sammanfattning : The increasingly hygienic life-style in Western societies may not only have reduced infections, but may also have altered the composition of the commensal microflora, which may, in turn, have predisposed to e.g. allergy development. Here we investigated the first year s intestinal colonization pattern of a Swedish birth-cohort. LÄS MER