Sökning: "Molekylär biofysik"

Visar resultat 1 - 5 av 59 avhandlingar innehållade orden Molekylär biofysik.

  1. 1. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins

    Författare :Eeva-Liisa Karjalainen; Andreas Barth; Astrid Gräslund; Timothy A. Keiderling; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Infrared spectroscopy; FTIR; protein; atpase; amyloid; caged compound; amide I; transition dipole coupling; exciton theory; simulation; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

    Sammanfattning : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. LÄS MER

  2. 2. NMR Investigations of Peptide-Membrane Interactions, Modulation of Peptide-Lipid Interaction as a Switch in Signaling across the Lipid Bilayer

    Författare :Sofia Unnerståle; Lena Mäler; Göran Widmalm; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; membrane mimetic; NMR; biophysics; Molecular biophysics; Molekylär biofysik; biofysik; Biophysics;

    Sammanfattning : The complexity of multi cellular organisms demands systems that facilitate communicationbetween cells. The neurons in our brains for instance are specialized in this cell-cellcommunication. LÄS MER

  3. 3. Biophysical investigations of ribonucleotide reductase : Activation and inhibition mechanisms

    Författare :Maria Öhrström; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; Biophysics; biofysik;

    Sammanfattning : Ribonucleotide reductase (RNR) is the enzyme responsible for de novo synthesis of deoxyribonucleotides, needed for both synthesis and repair of cellular DNA. The RNRs known so far are divided into three distinct classes; I, II and III. The conventional class I enzyme is composed of two separate subunits. LÄS MER

  4. 4. Protein Folding and DNA Origami

    Författare :Mark Marvin Seibert; David van der Spoel; Helmut Grubmüller; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; protein folding; Molecular Dynamics simulations; DNA origami; Biophysics; Biofysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Sammanfattning : In this thesis, the folding process of the de novo designed polypeptide chignolin was elucidated through atomic-scale Molecular Dynamics (MD) computer simulations. In a series of long timescale and replica exchange MD simulations, chignolin’s folding and unfolding was observed numerous times and the native state was identified from the computed Gibbs free-energy landscape. LÄS MER

  5. 5. The Application of isotropic bicelles as model membranes

    Författare :August Andersson; Lena Mäler; G Arthur III Palmer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bicelle; membrane; peptide; spectroscopy; NMR; Molecular biophysics; Molekylär biofysik;

    Sammanfattning : Isotropic bicelles are disc-shaped aggregates of lipids and detergents, and are suitable model systems for high-resolution NMR studies of membrane-interacting peptides. In this thesis the structures for the two peptides motilin and transportan were determined by homonuclear 1H methods in the presence of bicelles, and the structure of the bovine prion protein peptide (bPrPp) was solved in the presence of DHPC micelles. LÄS MER