Sökning: "NFkB"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet NFkB.

  1. 1. Regulation of immunoglobulin transcription

    Detta är en avhandling från BMC Biomedical Centre, Lund University

    Författare :David Liberg; Lund University.; Lunds universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; N-substituted benzamides; NFkB; transcription; B cells; immunoglobulin; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Each Ig V-region has its own upstream promoter and the promoter of a mature Ig gene is thereby selected during the V(D)J recombination process. Upon comparison, it is evident that only one transcription factor binding site, the octamer, is preserved within all promoters. LÄS MER

  2. 2. T cell Tolerance - Cellular and molecular features of immune regulation

    Detta är en avhandling från Susanna Grundström, Box 724, 220 07 Lund

    Författare :Susanna Grundström; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; JAK STAT.; NFkB; suppression; IL-2; superantigen; T cells; tolerance;

    Sammanfattning : The immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. LÄS MER

  3. 3. A peripheral immune response in Huntington's disease and delineation of its importance in disease pathology

    Detta är en avhandling från Lund University (Media-Tryck)

    Författare :Anna Magnusson-Lind; Lund University.; Lunds universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington s disease; peripheral symptoms; immune response; muscle atrophy; cytokines; gene expression; JAK STAT; NFkB; IL-6; TNF-alpha;

    Sammanfattning : Huntington’s disease (HD) is a fatal, hereditary disease for which there is no cure. It is caused by a mutation in a gene called huntingtin. HD is a so-called neurodegenerative disease, where there is a loss of neurons in areas of the brain that control body movements. This results in uncontrolled dance-like movements (chorea). LÄS MER

  4. 4. Astroglial Cells : Role in Neurodegenerative-Inflammatory Processes in the Central Nervous System

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Gun Eriksson; Stockholms universitet.; [1997]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; neurokemi och neurotoxikologi; Neurochemistry and Neurotoxicology;

    Sammanfattning : Inflammatory processes, mediated by the pro-inflammatory cytokines interleukin (IL) -1a/b, tumor necrosis factora(TNFa), IL-6 and excitotoxic actions of glutamate, are proposed to be implicated in neurodegenerative diseases, such as Alzheimer's disease.A neurotoxic fragment ofb-amyloid,bA25-35, was shown to induce a reactive phenotype of primary astrocytes and microglial cells in a time-dependent manner. LÄS MER

  5. 5. Transcriptional patterns in inflammatory disease

    Detta är en avhandling från Stockholm : KTH

    Författare :Johan Lindberg; KTH.; [2008]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; TECHNOLOGY Bioengineering; TEKNIKVETENSKAP Bioteknik;

    Sammanfattning : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. LÄS MER