Sökning: "sex-hormone binding globulin"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden sex-hormone binding globulin.

1. 1. Endogenous sex hormones and cardiometabolic risk factors – population-based studies within the Skaraborg Project

   Författare :Kristin Ottarsdottir; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sex hormones; sex hormone binding globulin; cardiometabolic risk factors; insulin resistance; post-menopause; cardiovascular diseases;

   Sammanfattning : Cardiovascular diseases are the major contributors to mortality in Sweden and globally. Men have a higher incidence of cardiovascular diseases compared to women, until women reach the menopause. Levels of sex hormones might explain these sex differences beyond known differences in risk factors. LÄS MER

3. 2. Endogenous hormones in the etiology of ovarian and endometrial cancers

   Författare :Annekatrin Lukanova; Eva Lundin; Pär Stattin; Rudolf Kaaks; Susan E. Hankinson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; ovarian cancer; endometrial cancer; sex-steroid hormones; sex-hormone binding globulin; insulin-like growth factor-I; insulin-like growth factor bidning proteins; C-peptide; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; epidemiologi; Epidemiology;

   Sammanfattning : The main purpose of this thesis was to examine the relationship of pre-diagnostic circulating levels of sex-steroids (androgens and estrogens), sex hormone binding globuline (SHBG), insulin-like growth factor-I (IGF-I), IGF binding proteins (BP) and C-peptide (as a marker of pancreatic insulin secretion) with risk of ovarian and endometrial cancer. Additionally, the interrelationships of body mass index (BMI), sex-steroids, IGF-I and IGFBP-3 were examined. LÄS MER

4. 3. The EGF-like Modules of Anticoagulant Protein S. Studies of Ca2+ binding and module interactions

   Författare :Yvonne Stenberg; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymology; Proteins; Klinisk kemi; Clinical chemistry; calcium binding; Protein S; EGF-like module; Proteiner; enzymologi;

   Sammanfattning : Protein S functions as a cofactor to activated protein C (APC) in the degradation of factors Va and VIIIa. In plasma protein S circulates in two forms; 30-40 % circulates as free protein S molecules while the remaining 60-70 % exists in a 1:1 complex with C4b-binding protein (C4BP). Only the free form of protein S functions as a cofactor to APC. LÄS MER

5. 4. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S

   Författare :Petra Evenäs; Malmö Klinisk kemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; tyrosine phosphorylation.; Sky receptor; SHBG-like region; protein S; G domain; Gas6; Activated protein C; C4b-binding protein; Proteins; enzymology; Proteiner; enzymologi;

   Sammanfattning : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. LÄS MER

7. 5. Obesity and Effects of Bariatric Surgery - with a Certain Focus on Women's Health

   Författare :Rebecca Paul; Torsten Olbers; Ellen Andersson; Jessica Frisk; Mikael Wirén; Mikaela Willmer; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sex hormones; Fertility; Women’s health; Obesity; Bariatric surgery; Experiences;

   Sammanfattning : Severe obesity influences sex hormone levels in women, which may result in subfertility, menstrual disturbances, anovulation and hyperandrogenism as well as increased risk for complications during pregnancy and birthing. Bariatric surgery leads to long-term weight loss and resolution of several comorbidities including hormone imbalance. LÄS MER