Sökning: "C-peptide"

Visar resultat 1 - 5 av 67 avhandlingar innehållade ordet C-peptide.

  1. 1. Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide

    Författare :Maria Thunander; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; type 2 diabetes; incidence; epidemiology; c-peptide; classification; antibodies; LADA; insulin; definition; autoimmune diseases; rheumatic antibodies; gastric antibodies; complications;

    Sammanfattning : Type 1 and type 2 diabetes increase worldwide, leading to a heavy burden of disease and its complications. All 1666 adults aged 18-100 years with new onset diabetes in Kronoberg during 3 years were registered, and type of diabetes classified by pancreatic autoantibodies and C-peptide. LÄS MER

  2. 2. Molecular aspects of proinsulin C-peptide interactions

    Författare :Mikael Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Diabetes mellitus; proinsulin C-peptide;

    Sammanfattning : Insulin biosynthesis in the beta-cells of the pancreas begins with the generation of preproinsulin, which is converted to proinsulin. Proinsulin is cleaved into equimolar amounts of insulin and connecting peptide (Cpeptide), which are released into the circulation. LÄS MER

  3. 3. Intracellular and peptide interactions of C-peptide

    Författare :Emma Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Proinsulin C-peptide is depleted together with insulin in type I diabetic patients. The supplement of insulin to these patients is necessary for their survival, but it is also likely that the loss of C-peptide may contribute to both short- and long-term complications. In this thesis, molecular effects of C-peptide have been investigated. LÄS MER

  4. 4. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide

    Författare :Lina Lindfors; Jan Kihlberg; Ingela Lanekoff; Fredrik Almqvist; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Diabetic kidney disease; Proinsulin C-peptide; GPR146; Mass spectrometry imaging; nano-DESI; Kemi; Chemistry;

    Sammanfattning : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. LÄS MER

  5. 5. Proinsulin C-peptide : Membrane interactions and intracellular signaling

    Författare :Zhihui Zhong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Human renal tubular cell; intracellular signal transduction; ERK1 2; JNK; Na ; K -A TPase; G-protein coupled receptor.;

    Sammanfattning : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. LÄS MER